March 30, 2015
Structures of human P2Y1 receptor bring new excitement to GPCR research.
SHANGHAI, CHINA - March 31, 2015 - A team of Chinese and US scientists has determined the high-resolution atomic structure of a
cell-surface receptor that plays a critical role in thrombosis, or blood clot, formation.
In a paper published in Nature on March 30 London time, the researchers at Shanghai Institute of Materia Medica (SIMM),
Chinese Academy of Sciences, collaborating with research groups from National Institutes of Health (NIH, U.S.),
Bridge Institute at University of Southern California (U.S.) and iHuman Institute of ShanghaiTech University (China),
provide a detailed molecular map of the human P2Y1 receptor (P2Y1R), a GPCR, in complex with a nucleotide
antagonist MRS2500 and a non-nucleotide antagonist BPTU.
March 2, 2015
The Bridge@USC brochure is now available online.
February 10, 2015
LOS ANGELES and SHANGHAI, /PRNewswire/ - The GPCR Consortium,
an international nonprofit collaboration that comprises
leading academic research institutes in the United States
and China and major pharmaceutical companies from around the world,
today announced two new members. Novo Nordisk and Merck & Co., Inc, known as MSD outside
the United States and Canada, have joined Amgen,
Sanofi and Ono in the GPCR Consortium, bringing the current pharma membership to five. The research funded by the GPCR Consortium is currently conducted
at the Bridge Institute at the University of Southern California, Shanghai Institute of Materia Medica, and the iHuman Institute at ShanghaiTech University.
January 23, 2015
Researchers at Bridge Institute at the University
of Southern California and University of California,
San Diego Skaggs School
of Pharmacy and Pharmaceutical Sciences report the first crystal structure of the cellular receptor CXCR4 bound
to an immune signaling protein called a chemokine. The structure, published Jan. 22 in Science, answers longstanding questions about a molecular interaction
that plays an important role in human development, immune responses, cancer metastasis and HIV infections.
January 6, 2015
Cherezov, Katritch, and Stevens 2014 Nature paper on δ-opioid and sodium signaling noted as one of the Science Signaling Breakthroughs of the Year.
January 1, 2015
Cherezov, Katritch, Kuhn and Stevens Labs move to the University of Southern California to start up
a NEW convergent biosciences institute
December 4, 2014
GPCR Consortium Plans – An open source industry-academia GPCR Consortium has been organized to accelerate GPCR structure-function studies
October 28, 2014
Los Angeles and Shanghai - New International GPCR Consortium Formed with Pharma and Academia to Advance Structural Information about G-protein Coupled Receptors
October 27, 2014
GPCR Industry-Academia Consortium announced
October 23, 2014
USC Michelson Convergence Building groundbreaking
August 5, 2014
July 10, 2014
Publication of Structural Basis for Smoothened Receptor Modulation and Chemoresistance to Anticancer Drugs in the journal Nature Communications
May 1, 2014
April 21, 2014
Review on allosteric role of sodium in class A GPCR signaling in TiBS on-line
March 23, 2014
Publication of Structure of the human P2Y12 receptor in the journal Nature
March 6, 2014
Publication of Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 in the journal Science
January 12, 2014
Publication of Molecular Control of δ-Opioid Receptor Signalling in the journal Nature
December 20, 2013
Publication of Serial Femtosecond Crystallography of G-Protein-Coupled Receptors in the journal Science
September 12, 2013
Publication of structure of the Human CCR5 Chemokine G-protein-coupled Receptor in the journal Science
July 17, 2013
Publication of Structure of the Human Glucagon Class B G-protein-coupled Receptor in the journal Nature
May 1, 2013
Publication of structure of the Human Smoothened Receptor in the journal Nature
March 21, 2013
March 19, 2013
GPCR Dock 2013 closed 3/2/2013. Results forthcoming this Summer, 2013
January 24, 2013
GPCR Dock 2013 starts February 1st.
Spread the word and Register NOW at>>
November 26, 2012
SAB meetings for JCIMPT and GPCR Network to plan for the future.
August 24, 2012
Due to repeated requests for figures and artwork, popular items are being made available to the community for use. You can download them HERE>>
August 1, 2012
Congratulations TSRI graduate student
Eugene Chun on receiving the 2012 Margaret C. Etter student award from the BioMacromolecular Special Interest Group at ACA for his work on the membrane protein (GPCR) fusion toolchest
July 13, 2012
June 5, 2012
May 17, 2012
March 21, 2012
Publication of kappa-opioid receptor structure in the journal Nature
For details click HERE >>
February 17, 2012
Publication of S1P1 receptor structure in the journal Science
For details click HERE >>
January 19, 2012
Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR - in Science Express
READ MORE >>
January 12, 2012
TiPS review on GPCR structural diversity and modularity
READ MORE >>
September 23, 2011
GPCR Network and JCIMPT-Complexes announce their Center and Scientific Advisory Board meetings to be held November 28-29, 2011 at TSRI
August 3, 2011
Wednesday, August 3, 2011 - PSI:Biology GPCR Network structure researchers hold first annual GPCR Network meeting.
June 22, 2011
In an international collaboration with the Iwata laboratory,
the human Histamine H1 receptor structure solved with 1st generation antihistamine.
May 12, 2011
GPCR Network Assessment Opens - ligand selection for opioid receptor MORE >>
March 10, 2011
Agonist bound structure of the A2A adenosine receptor highlights “conformationally selective agonist” published in Science Express.
November 19, 2010
November 17-18, 2010
3rd Annual NIH Roadmap to High Resolution Membrane Protein Structures Meeting to be held in La Jolla.
In addition, a special LCP hands on tools workshop will be held November 16th at the Scripps Research Institute led by Professor Vadim Cherezov.
For information, see more>>
October 7, 2010
5 structures of human CXCR4 chemokine GPCR published in Science more>>
September 14, 2010
GPCR Network established as a part of the NIH PSI:Biology program. For more information, see more>>
July 30, 2010
GPCR Dock 2010 assessment now closed to depositions, results to be announced in the early fall. For more information, please see more>>
June 4, 2010
GPCR Dock 2010 announced to evaluate the progress of GPCR modeling and docking in CXCR4 and D3 receptors. For more information, please see more>>
>February 1, 2010
3rd Annual NIH Roadmap meeting for membrane protein technologies Nov 17-18th in La Jolla more>>
> January 22, 2010
In collaboration with colleagues at UCSD and Leiden University,
structure based discovery of novel chemotypes for Adenosine A2A receptor antagonists more>>
> January 8, 2010
In collaboration with colleagues at Scripps Florida, dynamics of the human β2-adrenergic receptor revealed by hydrogen-deuterium exchange more>>
> June 1, 2009
Analysis of the GPCR Dock 2008 assessment is published in Nature Reviews Drug
> April 23, 2009
Scientists from the Stevens lab and Cravatt lab in collaboration with Pfizer,
Inc. discovered a potential new painkiller.
> January 16, 2009
Membrane Protein Postdoctoral Research Associate position available immediately more>>
> October 2, 2008
The Stevens Lab determined a 2.6 A structure of the human adenosine A2a receptor.
> June 11, 2008
The Stevens Lab established a Cholesterol Consensus Motif in GPCRs. more>>
> October 25, 2007