The Stevens Laboratory - Publications

To comply with copyright laws which preclude posting PDF files of actual reprints here, links are now included to each article’s PubMed entry (underlined & in red) or DOI entry (underlined & in green). Users may use these links to access full text or PDF versions of the papers as available. If you are unable to retrieve an article in this way, please request a copy by email from alwalker@scripps.edu.

Publications - 2008

227.         G.A. Asmar-Rovira, A.M. Asseo-Garcia, O. Quesada, M.A. Hanson, C. Nogueras, J.A. Lasalde-Dominicci, R.C. Stevens “Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments” J. Membr. Biol. In press (2008).

226.         L. Wang, A. Gamez, H. Archer, E.E. Abola, C.N. Sarkissian, P. Fitzpatrick, D. Wendt, Y. Zhang, M. Vellard, J. Bliesath, S. Bell, J. Lemont, C.R. Scriver, R.C. Stevens. “Structural and biochemical characterization of the therapeutic A. variabilis phenylalanine ammonia lyase” J. Mol. Biol. In press (2008). DOI:10.1016/j.jmb.2008.05.025

225.         M.A. Hanson, V. Cherezov, C.B. Roth, M.T. Griffith, V.-P. Jaakola, E.Y.T. Chien, J. Velasquez, P. Kuhn, R.C. Stevens “A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor” Structure, 16, 897-905 (2008). DOI:10.1016/j.str.2008.05.001 

224.         Q. Zhang, R. Horst, M. Geralt, X. Ma, W.X. Hong, M.G. Finn, R.C. Stevens, K. Wüthrich “Microscale NMR screening of new detergents for membrane protein structural biology” J. Am. Chem. Soc. 130, 7357-7363 (2008). DOI:10.1021/ja077863d

223.         J.D. Ng, R.C. Stevens, P. Kuhn “Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics” Methods Mol. Biol. 426, 363-376 (2008). DOI:10.1007/978-1-60327-058-8

222.         B.W. Neuman, J.S. Joseph, K.S. Saikatendu, P. Serrano, A. Chatterjee, M.A. Johnson, L. Liao, J.P. Klaus, J.R. Yates, K. Wüthrich, R.C. Stevens, M.J. Buchmeier, P. Kuhn “Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3” J. Virol. 82, 5279-5294, 2008. DOI:10.1128/JVI.02631-07

221.         A.I. Alexandrov, M. Mileni, E.Y.T. Chien, M.A. Hanson, R.C. Stevens “Microscale fluorescent thermal stability assay for membrane proteins” Structure 16, 351-359 (2008). DOI:10.1016/j.str.2008.02.004

220.         R. Jauch, C.K. Ng, K.S. Saikatendu, R.C. Stevens, P.R. Kolatkar “Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog” J. Mol. Biol. 376, 758-770 (2008). DOI:10.1016/j.jmb.2007.11.091 

219.         J.D. Ng, P.J. Clark, R.C. Stevens, P. Kuhn “In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels” Acta Crystallogr D 64, 189-197 (2008). DOI:10.1107/S0907444907060064

218.         C.B. Roth, M.A. Hanson, R.C. Stevens “Stabilization of the human β2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu-1223.41, A critical residue in GPCR structure” J. Mol. Biol. 376, 1305-1319 (2008). DOI:10.1016/j.jmb.2007.12.028  

217.         I.I. Mathews, D. McMullan, M.D. Miller, et al. "Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.3 Å resolution" Proteins 70, 603-608 (2008). DOI:10.1002/prot.21842

 

Publications - 2007

216.         R.C. Stevens “Generation of protein structures for the 21st century” Structure 15, 1517-1519 (2007). DOI:10.1016/j.str.2007.11.003

215.         D.M. Rosenbaum, V. Cherezov, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.-J. Choi, X.-J. Yao, W.I. Weis, R.C. Stevens, B.K. Kobilka “GPCR engineering provides high resolution structural insights into the function of the β2-adrenergic receptor” Science, 318, 1266-1273, (2007). DOI:10.1126/science.1150609

214.         V. Cherezov, D.M. Rosenbaum, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.-J. Choi, P. Kuhn, W.I. Weis, B.K. Kobilka, R.C. Stevens “High resolution crystal structure of human β2-adrenergic G protein coupled receptor” Science, 318, 1258-1265, (2007). DOI:10.1126/science.1150577

213.         M.R. Zurfluh, J. Zschocke, M. Linder, F. Feillet, C. Chery, A. Burlina, R.C. Stevens, B. Thony, and N. Blau. “Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency” Human Mut., 29, 167-175, (2007). DOI:10.1002/humu.20637

212.         P. Serrano, M.A. Johnson, M.S. Almeida, R. Horst, T. Herrmann, J.S. Joseph, B.W. Nueman, V. Subramanian, K.S. Saikatendu, M.J. Buchmeier, R.C. Stevens, P. Kuhn, and K. Wüthrich “NMR structure of the N-terminal domain of the nonstructural protein 3 from the SARS coronavirus” J. Virol. 81, 12049-12060, (2007). DOI:10.1128/JVI.00969-07

211.         Q. Zhang, X. Ma, A. Ward, W.X. Hong, V.P. Jaakola, R.C. Stevens, M.G. Finn, and G. Chang “Designing facial amphiphiles for the stabilization of integral membrane proteins” Angew. Chem. Int. Ed. Engl. 46, 7023-7025 (2007). DOI:10.1002/anie.200701556

210.         M.A. Hanson, A. Brooun, K.A. Baker, V.-P. Jaakola, C. Roth, E. Chien, A. Alexandrov, J. Velasquez, L. Davis, M. Griffith, K. Moy, B. Ganser-Pornillos, P. Kuhn, S. Ellis, M. Yeager, and R.C. Stevens “Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression” Protein Expr. Purific. 56, 85-92 (2007). DOI:10.1016/j.pep.2007.06.003

209.        L. Wang, S. Surendran, K. Michals-Matalon, G. Bhatia, S. Tanskley, R. Koch, J. Grady, S.K. Tyring, R.C. Stevens, F. Guttler, and R. Matalon “Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin” Genet. Test. 11, 174-178 (2007). DOI:10.1089/gte.2006.0520

208.        A. Gamez, L. Wang, C.N. Sarkissian, D. Wendt, P. Fitzpatrick, J.F. Lemontt, C.R. Scriver, C.R., and R.C. Stevens “Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of Phenylketonuria” Molec. Genet. Metab. 91, 325-334 (2007). DOI:10.1016/j.ymgme.2007.04.015

207.        E. Abola, D.D. Carlton, P. Kuhn, R.C. Stevens “Five years of increasing structural biology throughput. A retrospective analysis” in Structure Based Drug Discovery, Chapter 1, H. Jhoti and A. Leach, Eds., in press (2007).

206.        Stevens, R.C. and Yates, J.R. “You say functional, I say structural”, J. Proteome Res. 6, 927 (2007).

205.        J.S. Joseph, K.S. Saikatendu, V. Subramanian, B.W. Neuman, M.J. Buchmeier, R.C. Stevens, P. Kuhn. “Crystal structure of a monomeric form of SARS-CoV endonuclease nsp15 suggests a role for hexamerization as an allosteric switch” J. Virol. 81, 6700-6708 (2007). DOI:10.1128/JVI.02817-066

204.        K.S. Saikatendu, J.S. Joseph, V. Subramanian, B.W. Neuman, M.J. Buchmeier, R.C. Stevens, P. Kuhn. “Ribonucleocapsid Formation of Severe Acute Respiratory Syndrome Coronavirus through Molecular Action of the N-Terminal Domain of N Protein” J Virol. 81, 3913-21 (2007). DOI:10.1128/JVI.02236-06

203.        C. Garcia-Rodriguez, R. Levy, J.W. Arndt, C.M. Forsyth, A. Razai, J. Lou, I, Geren, R.C. Stevens, J.D. Marks “Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin” Nature Biotechnol. 25, 107-116 (2007). DOI:10.1038/nbt1269

 

Publications - 2006

202.        Q. Chai, J.W. Arndt, M. Dong, W.H. Tepp, E.A. Johnson, E.R. Chapman, R.C. Stevens. “Structural basis of cell surface receptor recognition by botulinum neurotoxin B” Nature 444, 1096-1100 (2006). DOI:10.1038/nature05411

201.        C.J. Gerdts, V. Tereshko, M.K. Yadav, I. Dementieva, F. Collart, A. Joachimiak, R.C. Stevens, P. Kuhn, A. Kossiakoff, R.F. Ismagilov “Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization.” Angew. Chem. Int. Ed. Engl. 45, 8156-8160 (2006). DOI:10.1002/anie.200602946

200.        R.C. Stevens “SPINE Forward” Acta Crystallogr. D62, 1 (2006).

199.        C.R. Scriver, M. Hurtubise, L. Prevost, M. Phommarinh, D. Konecki, H. Erlandsen, R.C. Stevens, P.J. Waters, S. Ryan, D. McDonald, C. Sarkissan “A PAH Gene Knowledgebase: Content, Informatics, Utilization” in PKU and BH4: Advances in Phenylketonuria and Tetrahydrobiopterin Research, N. Blau Ed., Keilbronn:SPS Verlagsgesellschaft, Pp. 434-451 (2006).

198.        E. Abola, P. Kuhn, R.C. Stevens “Miniaturization of the structural biology technologies – From expression to biophysical analyses” in Structural Genomics on Membrane Proteins. K. Lundstrom, Ed., CRC Press: Boca Raton, FL. Pp. 299-320, (2006).

197.        Q. Xu, S.S. Krishna, D. McMullan, et al. “Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 Å resolution reveals a fold similar to the Ran-binding protein Mog1p” Proteins 65, 777-782 (2006). DOI:10.1002/prot.21015

196.        M. DiDonato, S.S. Krishna, R. Schwarzenbacher, et al. “Crystal structure of 2-phosphysulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 Å resolution reveals a new fold with a novel active site” Proteins 65, 771-776 (2006). DOI:10.1002/prot.20978

195.        M. Kosloff, G.W. Han, S.S. Krishna, et al. “ Comparative structural analysis of a novel glutathione S-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 Å resolution.” Proteins 65, 527-537 (2006). DOI:10.1002/prot.21130

194.        J.W. Arndt, M.J. Jacobson, E.E. Abola, W.H. Tepp, E.A. Johnson, R.C. Stevens “A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4” J. Mol. Biol. 362, 733-742 (2006). DOI:10.1016/j.jmb.2006.07.040

193.        I.I. Mathews, S.S. Krishna, R. Schwarzenbacher, et al. “Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 Å resolution” Proteins 65, 249-254 (2006). DOI:10.1002/prot.21024

192.        R. Schwarzenbacher, D. McMullan, S.S. Krishna, et al. “Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 Å resolution reveals a new fold” Proteins 65, 243-248 (2006). DOI:10.1002/prot.21058

191.        G.W. Han, S.S. Krishna, R. Schwarzenbacher, et al. “Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å resolution” Proteins 64, 1083-1090 (2006). DOI:10.1002/prot.20950

190.        Q. Xu, R. Schwarzenbacher, S.S. Krishna, et al. “Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 Å resolution” Proteins 64, 808-813 (2006). DOI:10.1002/prot.20947

189.        J.S. Joseph, K.S. Saikatendu, V. Subramanian, B.W. Neuman, A. Brooun, M. Griffith, K. Moy, M.K. Yadav, J. Velazquez, M.J. Buchmeier, R.C. Stevens, P. Kuhn “Crystal structure of non-structural protein-10 (nsp10) from the SARS coronavirus reveals a novel fold with two zinc-binding motifs” J. Virol. 80, 7894-7901 (2006). DOI:10.1128/JVI.00467-06

188.        K.K. Jin, S.S. Krishna, R. Schwarzenbacher, et al. “Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold” Proteins 63, 1112-1118 (2006). DOI:10.1002/prot.20894

187.        I. Mathews, S.S. Krishna, R. Schwarzenbacher et al. “Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution” Proteins 63, 1106-1111 (2006). DOI:10.1002/prot.20650

186.        K. Ratia, K.S. Saikatendu, B.D. Santarsiero, N. Barretto, S.C. Baker, R.C. Stevens, A.D. Mesecar “Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme” Proc. Natl. Acad. Sci. USA, 103, 5717-5722 (2006). DOI:10.1073/pnas.0510851103

185.        J.W. Arndt, Q. Chai, T. Christian, R.C. Stevens "Structure of botulinum neurotoxin type D light chain at 1.65 Å resolution - Repercussions into VAMP-2 substrate specificity" Biochemistry 45, 3255-3262 (2006). DOI:10.1021/bi052518r

184.        M. DiDonato, S. Sri Krishna, R. Schwarzenbacher, et al. “Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 Å resolution” Proteins, 63, 256-260 (2006). PMID:16435371

183.        Q. Xu, R. Schwarzenbacher, D. McMullan, et al. “Crystal structure and virulence factor CJ0248 from Campylobacter jejuni at 2.25Å resolution reveals a new fold“ Proteins, 62, 292-296 (2006). PMID:16287129

 

Publications - 2005

182.        R. Matalon, K. Michals-Matalon, R. Koch, J. Grady, S. Tyring, R.C. Stevens “Response of patients with phenylketonuria in the US to tetrahydrobiopterin” Mol. Genet. Metab.  86 Suppl 1, 17-21 (2005). PMID:16143554

181.        B. Pérez, L.R. Desviat, P. Gómez-Puertas, A. Martínez, R.C. Stevens, M. Ugarte “Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients” Mol. Genet. Metab. 86 Suppl 1, 11-16 (2005). PMID:16091306

180.        N. Blau, R. Koch, R. Matalon, R.C. Stevens “Five years of synergistic scientific effort on phenylketonuria therapeutic development and molecular understanding” Mol. Genet. Metab. 86 Suppl 1, 1 (2005). PMID:16165385

179.        S. Swaminathan, R.C. Stevens “Three dimensional protein structures of botulinum neurotoxin light chains serotypes A, B, and E” in Treatments from Toxins: The therapeutic potential of clostridial neurotoxins, Eds. K. Foster, P. Hambleton, C. Shone, CRC Press:Boca Raton, FL, in press (2005).

178.        M.K. Yadav, C.J. Gerdts, R. Sanishvili, W.W. Smith, L.S. Roach, R.F. Ismagilov, P. Kuhn, R.C. Stevens “In situ data collection and structure refinement from microcapillary protein crystallization” J. Appl. Crystallogr. 38, 900-905 (2005). DOI:10.1107/S002188980502649X

177.        B. Collins, R.C. Stevens, R. Page “Crystallization optimum solubility screening: Using crystallization results to identify the optimal buffer for protein crystal formation” Acta Crystallogr. F61, 1035-1038 (2005). PMID:16511228

176.        K.S. Saikatendu, J.S. Joseph, V. Subramanian, T. Clayton, M. Griffith, K. Moy, J. Velasquez, B.W. Neuman, M.J. Buchmeier, R.C. Stevens, P. Kuhn “Structural basis of severe acute respiratory syndrome coronavirus ADP-Ribose 1˝-phosphate dephosphorylation by a conserved domain of nsP3” Structure 13, 1665-1675 (2005). PMID:16271890

175.        W. Peti, M.A. Johnson, T. Hermann, B.W. Newman, M.J. Buchmeier, M. Nelson, J. Joseph, R. Page, R.C. Stevens, P. Kuhn, K. Wüthrich "Structural genomics of the severe acute respiratory syndrome coronavirus: Nuclear magnetic resonance structure of the protein nsP7" J. Virol. 79, 12905-12913 (2005). PMID:16188992

174.        H.E. Klock, R. Schwarzenbacher, Q. Xu, et al. “Crystal structure of a conserved hypothetical protein (gi: 13879369) from mouse at 1.90Å resolution reveals a new fold” Proteins, 61, 1132-1136 (2005). PMID:16224779

173.        L. Jaroszewski, R. Schwarzenbacher, D. McMullan, et al. “Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20Å resolution“ Proteins 61, 669-673 (2005) PMID:16167343

172.        C. Rife, R. Schwarzenbacher, D. McMullan, et al. “Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 Å resolution reveals a new fold." Proteins, 61, 444-448 (2005). PMID:16104019

171.        C. Rife, R. Schwarzenbacher, D. McMullan, et al. "Crystal structure of a global regulatory protein CsrA from Pseudomonas putida at 2.05Å resolution reveals a new fold" Proteins 61, 449-453 (2005). PMID:16104018

170.        J.W. Arndt, W. Yu, F. Bi, R.C. Stevens “Crystal structure of botulinum neurotoxin type G light chain - Serotype divergence in substrate recognition” Biochemistry. 44, 9574-9580 (2005). PMID:16008342

169.        L. Wang, A. Gamez, C.N. Sarkissian, M. Straub, M.G. Patch, G.W. Han, S. Striepeke, P. Fitzpatrick, C.R. Scriver, R.C. Stevens “Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria” Mol. Genet. Metab. 86, 134-140 (2005). PMID:16006165

168.        W. Peti, R. Page, K. Moy, M. O’Neil-Johnson, I.A. Wilson, R.C. Stevens, K. Wüthrich “Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR” J. Struct. Funct. Genomics, on-line November 9, 2005. (2005). PMID:16283429

167.        J.S. Ricci, R.C. Stevens, R.K. McMullan, W.T. Klooster “Structure of strontium hydroxide octahydrate, Sr(OH)2.8H2O at 20, 100 and 200 K from neutron diffraction” Acta Crystallogr. B61, 381-386 (2005). PMID:16041087

166.        J.S. Chappie, J.M. Cànaves, G.W. Han, C.L. Rife, Q. Xu, R.C. Stevens. “The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases” Structure, 13, 1385-1396 (2005). PMID:16154095

165.        A. Gámez, C.N. Sarkissian, L. Wang, W. Kim, M. Straub, M.G. Patch, L. Chen, S. Striepeke, P. Fitzpatrick, J.F. Lemontt, C. O’Neill, C.R. Scriver, R.C. Stevens. “Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria” Mol. Ther., 11, 986-989 (2005). PMID:15922970

164.        G.W. Han, R. Schwarzenbacher, D. McMullan, et al. “Crystal structure of an apo mRNA decapping enzyme (DcpS) from mouse at 1.83Å resolution” Proteins 60, 797-802 (2005). PMID:16001405

163.        I. Levin, M.D. Miller, R. Schwarzenbacher, et al. “Crystal structure of an indigoidine synthase A (IndA) like protein (TM1464) from Thermotoga maritima at 1.90 Å resolution reveals a new fold.” Proteins, 59, 864-868 (2005). PMID:15822122

162.        I. Mathews, R. Schwarzenbacher, D. McMullan, et al. "Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold” Proteins, 59, 869-874, (2005). PMID:15822125

161.        R. Page, A.M. Deacon, S.A. Lesley, R. C. Stevens “Shotgun crystallization strategy for structural genomics II:  Crystallization conditions that produce high resolution structures for T. maritima proteins” J. Funct. Struct. Genomics, 6, 209-217 (2005). PMID:16211521

160.        R. Page, W. Peti, I.A. Wilson, R. Stevens, K. Wüthrich  “NMR screening of mouse homolog proteins in a structural proteomics pipeline" Proc. Natl. Acad. Sci. USA, 102, 1901-1905 (2005). PMID:15677718

159.        C.R. Scriver, M. Hurtubise, L. Prevost, M. Phommarinh, D. Konecki, H. Erlandsen, R.C. Stevens, P.J. Waters, S. Ryan, D. McDonald, C. Sarkissan “A PAH gene knowledgebase: Content, informatics, utilization” in PKU and BH4: Advances in Phenylketonuria and Tetrahydrobiopterin Research, N. Blaue (Ed.), in press (2005).

158.        J. W. Arndt, J.Gu, L.Jaroszewski, R.Schwarzenbacher, M.A. Hanson, F.J. Lebeda, R.C. Stevens “The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring b-trefoil fold in the progenitor toxin complex” J. Mol. Biol. 346, 1083-1093 (2005). PMID:15701519

157.        D.C. Carter, P. Rhodes, D.E. McRee, L. Tari, D.R. Dougan, G. Snell, E. Abola, R.C. Stevens “Reduction in diffuse-convective disturbances in nanovolume protein crystallization experiments” J. Appl. Crystallogr., 38, 87-90 (2005). DOI:10.1107/S0021889804028055

156.        Q. Xu, R. Schwarzenbacher, D. McMullen, et al. “Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 Å resolution reveals a new fold.” Proteins, 58, 976-981 (2005). PMID:15651027

155.        G.W. Han, R. Schwarzenbacher, R. Page, et al. “Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70Å resolution reveals a noncovalently linked PLPcofactor“ Proteins, 58, 971-975 (2005). PMID:15657930

154.        J.W. Arndt, R. Schwarzenbacher, R. Page, et al. “Crystal structure of an a/b serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution” Proteins, 58, 755-758 (2005). PMID:15624212

 

Publications - 2004

153.        J.M. Canaves, R. Page, R.C. Stevens "Protein biophysical properties that correlate with crystallization success in Thermotoga Maritima: Maximum clustering strategy for structural genomics" J. Mol. Biol., 344, 977-991 (2004). PMID:15544807

152.        H. Erlandsen, A.L. Pey, A. Gámez, B. Pérez, L.R. Desviat, C. Aguado, R. Koch, S. Surendrran, T. Tyring, R. Matalon, C.R. Scriver, M. Ugarte, A. Martínez, R.C. Stevens “Correction of kinetic and stability dfects by the cofactor BH4 in PKU patients with certain phenylalanine hydroxylase mutations” Proc. Natl. Acad. Sci. USA, 101, 16903-16908 (2004). PMID:15557004

151.        A.L. Pey, B. Perez, L.R. Desviat, M.A. Martinez, H. Erlandsen, A. Gamez, R.C. Stevens, M. Ugarte, A. Martinez “Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations” Human Mutations, 24, 388-399 (2004). PMID:15459954

150.        J. Song, R.C. Stevens, Q. Cheng "Functional amphiphilic and bolaamphiphilic poly(diacetylene) assemblies with controlled optical and morphological properties" in Chromogenic Phenomena in Polymers: Tunable Optical Properties, S.A. Jenekhe & D.J. Kiserow (Eds.), Amer. Chem. Soc.: Oxford. pp. (2004).

149.        M.D. Miller, R. Schwarzenbacher, F. von Delft et al. “Crystal structure of a tandem cystathionine-b-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 Å resolution” Proteins 57, 213-217(2004). PMID:15326606

148.        R. Page, R.C. Stevens "Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens" Methods, 34, 373-389 (2004). PMID:15325655

147.        R. Page, K. Moy, E.C. Sims, J. Velasquez, B. McManus, C. Grittini, T.L. Clayton, R.C. Stevens “Scalable high-throughput micro-expression device for recombinant proteins” BioTechniques, 37, 364-370 (2004) PMID:15470889

146.        W. Kim, H. Erlandsen, S. Surendran, R.C. Stevens, A. Gamez, K. Michols-Matalon, S.K. Tyring, R. Matalon “Trends in enzyme replacement therapy for PKU” Mol. Ther., 10, 220-224 (2004). PMID:15294168

145.        I. Levin, R. Schwarzenbacher, D. McMullan et al. “Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 Å resolution” Proteins, 56, 629-633 (2004). PMID:15229897

144.        Q. Xu, R. Schwarzenbacher, R. Page et al. “Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 Å resolution” Proteins, 56, 619-624 (2004). PMID:15229895

143.        D. McMullan, R. Schwarzenbacher, L. Jaroszewski et al. “Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 Å resolution” Proteins, 56, 615-618 (2004). PMID:15229894

142.        L. Jaroszewski, R. Schwarzenbacher, F. von Delft et al. “Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution” Proteins, 56, 611-614 (2004).