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Publications - 2012

286.	Author: E. E. Abola, V. Cherezov and R. C. Stevens Year: 2012 Title: X-ray crystallography: crystallization Secondary Author: E. H. Egelman Secondary Title: Comprehensive Biophysics Place Published: Oxford Publisher: Academic Press Volume: 1 Pages: 34-63 Tertiary Author: H. J. Dyson Tertiary Title: Biophysical Techniques for Structural Characterization of Macromolecules Short Title: X-ray crystallography: crystallization
285.	E. Chun, A. A. Thompson, W. Liu, C. B. Roth, M. T. Griffith, V. Katritch, J. Kunken, F. Xu, V. Cherezov, L. H. Heitman, A. P. IJzerman, M. A. Hanson and R. C. Stevens (2012) Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors Structure
284.	F. Deflorian, T. S. Kumar, K. Phan, Z. G. Gao, F. Xu, H. Wu, V. Katritch, R. C. Stevens and K. A. Jacobson (2012) Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A(2)A adenosine receptor J Med Chem 55: 538-52 ;
283.	D. M. Ferrero, D. Wacker, M. A. Roque, M. W. Baldwin, R. C. Stevens and S. D. Liberles (2012) Agonists for 13 Trace Amine-Associated Receptors Provide Insight into the Molecular Basis of Odor Selectivity ACS Chem Biol
282.	M. A. Hanson, C. B. Roth, E. Jo, M. T. Griffith, F. L. Scott, G. Reinhart, H. Desale, B. Clemons, S. M. Cahalan, S. C. Schuerer, M. G. Sanna, G. W. Han, P. Kuhn, H. Rosen and R. C. Stevens (2012) Crystal structure of a lipid G protein-coupled receptor Science 335: 851-5 ;
281.	V. Katritch, V. Cherezov and R. C. Stevens (2012) Diversity and modularity of G protein-coupled receptor structures Trends Pharmacol Sci 33: 17-27 ;
280.	J. J. Liu, R. Horst, V. Katritch, R. C. Stevens and K. Wuthrich (2012) Biased signaling pathways in beta2-adrenergic receptor characterized by 19F-NMR Science 335: 1106-10 ;
279.	A. A. Thompson, W. Liu, E. Chun, V. Katritch, H. Wu, E. Vardy, X. P. Huang, C. Trapella, R. Guerrini, G. Calo, B. L. Roth, V. Cherezov and R. C. Stevens (2012) Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Nature 485: 395-399 ;
278.	D. K. Tosh, K. Phan, Z. G. Gao, A. A. Gakh, F. Xu, F. Deflorian, R. Abagyan, R. C. Stevens, K. A. Jacobson and V. Katritch (2012) Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening J Med Chem 55: 4297-308 ;
277.	H. Wu, D. Wacker, M. Mileni, V. Katritch, G. W. Han, E. Vardy, W. Liu, A. A. Thompson, X. P. Huang, F. I. Carroll, S. W. Mascarella, R. B. Westkaemper, P. D. Mosier, B. L. Roth, V. Cherezov and R. C. Stevens (2012) Structure of the human kappa-opioid receptor in complex with JDTic Nature 485: 327-332 ;

Publications - 2011

276.	C. Ezzili, M. Mileni, N. McGlinchey, J. Z. Long, S. G. Kinsey, D. G. Hochstatter, R. C. Stevens, A. H. Lichtman, B. F. Cravatt, E. J. Bilsky and D. L. Boger (2011) Reversible Competitive alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics J Med Chem 54: 2805-22 ;
275.	M. J. Jacobson, G. Lin, W. Tepp, J. Dupuy, P. Stenmark, R. C. Stevens and E. A. Johnson (2011) Purification, Modeling and Analysis of Neurotoxin BoNT/A5 from Clostridium botulinum Strain A661222 Appl Environ Microbiol
274.	I. Kufareva, M. Rueda, V. Katritch, R. C. Stevens and R. Abagyan (2011) Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment Structure 19: 1108-26 ;
273.	M. Mileni, J. Garfunkle, C. Ezzili, B. F. Cravatt, R. C. Stevens and D. L. Boger (2011) Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase J Am Chem Soc 133: 4092-100 ;
272.	M. T. Miller, M. Mileni, D. Comoletti, R. C. Stevens, M. Harel and P. Taylor (2011) The Crystal Structure of the alpha-Neurexin-1 Extracellular Region Reveals a Hinge Point for Mediating Synaptic Adhesion and Function Structure 19: 767-78 ;
271.	C. N. Sarkissian, A. Gamez, P. Scott, J. Dauvillier, A. Dorenbaum, C. R. Scriver and R. C. Stevens (2011) Chaperone-like therapy with tetrahydrobiopterin in clinical trials for phenylketonuria: is genotype a predictor of response? JIMD Reports Online:
270.	C. N. Sarkissian, T. S. Kang, A. Gamez, C. R. Scriver and R. C. Stevens (2011) Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria Mol Genet Metab 104: 249-254 ;
269.	T. Shimamura, M. Shiroishi, S. Weyand, H. Tsujimoto, G. Winter, V. Katritch, R. Abagyan, V. Cherezov, W. Liu, G. W. Han, T. Kobayashi, R. C. Stevens and S. Iwata (2011) Structure of the human histamine H(1) receptor complex with doxepin Nature 475: 65-70 ;
268.	A. A. Thompson, G. S. Jiao, S. Kim, A. Thai, L. Cregar-Hernandez, S. A. Margosiak, A. T. Johnson, G. W. Han, S. O'Malley and R. C. Stevens (2011) Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the Clostridium botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility Biochemistry 50: 4019-28 ;
267.	A. A. Thompson, J. J. Liu, E. Chun, D. Wacker, H. Wu, V. Cherezov and R. C. Stevens (2011) GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles Methods 55: 310-7 ;
266.	G. M. West, E. Y. Chien, V. Katritch, J. Gatchalian, M. J. Chalmers, R. C. Stevens and P. R. Griffin (2011) Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR beta(2) Adrenergic Receptor Revealed by HDX Structure
265.	F. Xu, W. Liu, M. A. Hanson, R. C. Stevens and V. Cherezov (2011) Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases Cryst Growth Des 11: 1193-1201 ;
264.	F. Xu and R. C. Stevens (2011) Trapping Small Caffeine in a Large GPCR Pocket Structure 19: 1204-7 ;
263.	F. Xu, H. Wu, V. Katritch, G. W. Han, K. A. Jacobson, Z. G. Gao, V. Cherezov and R. C. Stevens (2011) Structure of an agonist-bound human A2A adenosine receptor Science 332: 322-7 ;

Publications - 2010

262.	V. Cherezov, E. Abola and R. C. Stevens (2010) Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets Methods Mol Biol 654: 141-68 ;
261.	E. Y. Chien, W. Liu, Q. Zhao, V. Katritch, G. W. Han, M. A. Hanson, L. Shi, A. H. Newman, J. A. Javitch, V. Cherezov and R. C. Stevens (2010) Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist Science 330: 1091-5 ;
260.	J. Dong, A. A. Thompson, Y. Fan, J. Lou, F. Conrad, M. Ho, M. Pires-Alves, B. A. Wilson, R. C. Stevens and J. D. Marks (2010) A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region J Mol Biol 397: 1106-1118 ;
259.	W. X. Hong, K. A. Baker, X. Ma, R. C. Stevens, M. Yeager and Q. Zhang (2010) Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26 Langmuir 26: 8690-6 ;
258.	V. P. Jaakola, J. R. Lane, J. Y. Lin, V. Katritch, A. P. Ijzerman and R. C. Stevens (2010) Identification and characterization of amino acid residues essential for human A2A adenosine receptor : ZM241385 binding and subtype selectivity J Biol Chem 285: 13032-13044 ;
257.	T. S. Kang, L. Wang, C. N. Sarkissian, A. Gamez, C. R. Scriver and R. C. Stevens (2010) Converting an injectable protein therapeutic into an oral form: Phenylalanine ammonia lyase for phenylketonuria Mol Genet Metab 99: 4-9 ;
256.	V. Katritch, V. P. Jaakola, J. R. Lane, J. Lin, A. P. Ijzerman, M. Yeager, I. Kufareva, R. C. Stevens and R. Abagyan (2010) Structure-Based Discovery of Novel Chemotypes for Adenosine A(2A) Receptor Antagonists J Med Chem 53: 1799-1809 ;
255.	W. Liu, M. A. Hanson, R. C. Stevens and V. Cherezov (2010) LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment Biophys J 98: 1539-48 ;
254.	M. Michino, J. Chen, R. C. Stevens and C. L. Brooks, 3rd (2010) FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A Proteins 78: 2189-201 ;
253.	M. Mileni, J. Garfunkle, C. Ezzili, F. S. Kimball, B. F. Cravatt, R. C. Stevens and D. L. Boger (2010) X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase J Med Chem 53: 230-40 ;
252.	M. Mileni, S. Kamtekar, D. C. Wood, T. E. Benson, B. F. Cravatt and R. C. Stevens (2010) Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation J Mol Biol 400: 743-54 ;
251.	F. Y. Siu and R. C. Stevens (2010) RAMP-ing up class-B GPCR ECD structural coverage Structure 18: 1067-8 ;
250.	P. Stenmark, M. Dong, J. Dupuy, E. R. Chapman and R. C. Stevens (2010) Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding J Mol Biol 397: 1287-97 ;
249.	R. C. Stevens, J. Sancho and A. Martinez (2010) Rescue of misfolded proteins and stabilization by small molecules Methods Mol Biol 648: 313-24 ;
248.	C. G. Tate and R. C. Stevens (2010) Growth and excitement in membrane protein structural biology Curr Opin Struct Biol 20: 399-400 ;
247.	D. Wacker, G. Fenalti, M. A. Brown, V. Katritch, R. Abagyan, V. Cherezov and R. C. Stevens (2010) Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography J Am Chem Soc 132: 11443-5 ;
246.	B. Wu, E. Y. Chien, C. D. Mol, G. Fenalti, W. Liu, V. Katritch, R. Abagyan, A. Brooun, P. Wells, F. C. Bi, D. J. Hamel, P. Kuhn, T. M. Handel, V. Cherezov and R. C. Stevens (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Science 330: 1066-71 ;
245.	X. Zhang, E. Y. Chien, M. J. Chalmers, B. D. Pascal, J. Gatchalian, R. C. Stevens and P. R. Griffin (2010) Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange Anal Chem 82: 1100-8 ;

Publications - 2009

244.	K. Ahn, D. S. Johnson, M. Mileni, D. Beidler, J. Z. Long, M. K. McKinney, E. Weerapana, N. Sadagopan, M. Liimatta, S. E. Smith, S. Lazerwith, C. Stiff, S. Kamtekar, K. Bhattacharya, Y. Zhang, S. Swaney, K. Van Becelaere, R. C. Stevens and B. F. Cravatt (2009) Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain Chem Biol 16: 411-20 ;
243.	V. Cherezov, M. A. Hanson, M. T. Griffith, M. C. Hilgart, R. Sanishvili, V. Nagarajan, S. Stepanov, R. F. Fischetti, P. Kuhn and R. C. Stevens (2009) Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam J R Soc Interface 6 Suppl 5: S587-97 ;
242.	M. A. Hanson and R. C. Stevens (2009) Discovery of new GPCR biology: one receptor structure at a time Structure 17: 8-14 ;
241.	V. P. Jaakola, Stevens, R.C. (2009) G Protein-Coupled Receptors Handbook of Cell Signalling
240.	T. S. Kang and R. C. Stevens (2009) Structural aspects of therapeutic enzymes to treat metabolic disorders Hum Mutat 30: 1591-610 ;
239.	V. Katritch, K. A. Reynolds, V. Cherezov, M. A. Hanson, C. B. Roth, M. Yeager and R. Abagyan (2009) Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes J Mol Recognit 22: 307-18 ;
238.	M. Michino, E. Abola, C. L. Brooks, 3rd, J. S. Dixon, J. Moult and R. C. Stevens (2009) Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 Nat Rev Drug Discov 8: 455-63 ;
237.	M. Mileni, J. Garfunkle, J. K. DeMartino, B. F. Cravatt, D. L. Boger and R. C. Stevens (2009) Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures J Am Chem Soc 131: 10497-506 ;
236.	M. Mileni, J. Garfunkle, C. Ezzili, F. S. Kimball, B. F. Cravatt, R. C. Stevens and D. L. Boger (2009) X-ray Crystallographic Analysis of alpha-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase J Med Chem 53: 230-240 ;

Publications - 2008

235.	E. E. Abola and R. C. Stevens (2008) The importance of target selection strategies in structural biology J. L. Sussman and I. Silman Structural proteomics and its impact on the life sciences Singapore World Scientific Publishing Co. 1-28
234.	A. I. Alexandrov, M. Mileni, E. Y. Chien, M. A. Hanson and R. C. Stevens (2008) Microscale fluorescent thermal stability assay for membrane proteins Structure 16: 351-9 ;
233.	G. A. Asmar-Rovira, A. M. Asseo-Garcia, O. Quesada, M. A. Hanson, A. Cheng, C. Nogueras, J. A. Lasalde-Dominicci and R. C. Stevens (2008) Biophysical and Ion Channel Functional Characterization of the Torpedo californica Nicotinic Acetylcholine Receptor in Varying Detergent-Lipid Environments J Membr Biol 223: 13-26 ;
232.	K. T. Barglow, K. S. Saikatendu, M. H. Bracey, R. Huey, G. M. Morris, A. J. Olson, R. C. Stevens and B. F. Cravatt (2008) Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes Biochemistry 47: 13514-23 ;
231.	V. Cherezov, J. Liu, M. Griffith, M. A. Hanson and R. C. Stevens (2008) LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization Cryst Growth Des 8: 4307-4315 ;
230.	S. Graslund, P. Nordlund, J. Weigelt, B. M. Hallberg, J. Bray, O. Gileadi, S. Knapp, U. Oppermann, C. Arrowsmith, R. Hui, J. Ming, S. dhe-Paganon, H. W. Park, A. Savchenko, A. Yee, A. Edwards, R. Vincentelli, C. Cambillau, R. Kim, S. H. Kim, Z. Rao, Y. Shi, T. C. Terwilliger, C. Y. Kim, L. W. Hung, G. S. Waldo, Y. Peleg, S. Albeck, T. Unger, O. Dym, J. Prilusky, J. L. Sussman, R. C. Stevens, S. A. Lesley, I. A. Wilson, A. Joachimiak, F. Collart, I. Dementieva, M. I. Donnelly, W. H. Eschenfeldt, Y. Kim, L. Stols, R. Wu, M. Zhou, S. K. Burley, J. S. Emtage, J. M. Sauder, D. Thompson, K. Bain, J. Luz, T. Gheyi, F. Zhang, S. Atwell, S. C. Almo, J. B. Bonanno, A. Fiser, S. Swaminathan, F. W. Studier, M. R. Chance, A. Sali, T. B. Acton, R. Xiao, L. Zhao, L. C. Ma, J. F. Hunt, L. Tong, K. Cunningham, M. Inouye, S. Anderson, H. Janjua, R. Shastry, C. K. Ho, D. Wang, H. Wang, M. Jiang, G. T. Montelione, D. I. Stuart, R. J. Owens, S. Daenke, A. Schutz, U. Heinemann, S. Yokoyama, K. Bussow and K. C. Gunsalus (2008) Protein production and purification Nat Methods 5: 135-46 ;
229.	M. A. Hanson, V. Cherezov, M. T. Griffith, C. B. Roth, V. P. Jaakola, E. Y. Chien, J. Velasquez, P. Kuhn and R. C. Stevens (2008) A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor Structure 16: 897-905 ;
228.	L. G. Holden, C. Prochnow, Y. P. Chang, R. Bransteitter, L. Chelico, U. Sen, R. C. Stevens, M. F. Goodman and X. S. Chen (2008) Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications Nature 456: 121-4 ;
227.	V. P. Jaakola, M. T. Griffith, M. A. Hanson, V. Cherezov, E. Y. Chien, J. R. Lane, A. P. Ijzerman and R. C. Stevens (2008) The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist Science
226.	R. Jauch, C. K. Ng, K. S. Saikatendu, R. C. Stevens and P. R. Kolatkar (2008) Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog J Mol Biol 376: 758-70 ;
225.	I. I. Mathews, D. McMullan, M. D. Miller, J. M. Canaves, M. A. Elsliger, R. Floyd, S. K. Grzechnik, L. Jaroszewski, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, T. M. McPhillips, A. T. Morse, K. Quijano, C. L. Rife, R. Schwarzenbacher, G. Spraggon, R. C. Stevens, H. van den Bedem, D. Weekes, G. Wolf, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley and I. A. Wilson (2008) Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution Proteins 70: 603-8 ;
224.	M. Mileni, D. S. Johnson, Z. Wang, D. S. Everdeen, M. Liimatta, B. Pabst, K. Bhattacharya, R. A. Nugent, S. Kamtekar, B. F. Cravatt, K. Ahn and R. C. Stevens (2008) Structure-guided inhibitor design for human FAAH by interspecies active site conversion Proc Natl Acad Sci U S A 105: 12820-4 ;
223.	B. W. Neuman, J. S. Joseph, K. S. Saikatendu, P. Serrano, A. Chatterjee, M. A. Johnson, L. Liao, J. P. Klaus, J. R. Yates, 3rd, K. Wuthrich, R. C. Stevens, M. J. Buchmeier and P. Kuhn (2008) Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3 J Virol 82: 5279-94 ;
222.	J. D. Ng, P. J. Clark, R. C. Stevens and P. Kuhn (2008) In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels Acta Crystallogr D Biol Crystallogr 64: 189-97 ;
221.	J. D. Ng, R. C. Stevens and P. Kuhn (2008) Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics Methods Mol Biol 426: 363-76 ;
220.	C. B. Roth, M. A. Hanson and R. C. Stevens (2008) Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure J Mol Biol 376: 1305-19 ;
219.	C. N. Sarkissian, A. Gamez, L. Wang, M. Charbonneau, P. Fitzpatrick, J. F. Lemontt, B. Zhao, M. Vellard, S. M. Bell, C. Henschell, A. Lambert, L. Tsuruda, R. C. Stevens and C. R. Scriver (2008) Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria Proc Natl Acad Sci U S A 105: 20894-9 ;
218.	I. M. Slaymaker, M. Bracey, M. Mileni, J. Garfunkle, B. F. Cravatt, D. L. Boger and R. C. Stevens (2008) Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase Bioorg Med Chem Lett
217.	P. Stenmark, J. Dupuy, A. Imamura, M. Kiso and R. C. Stevens (2008) Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction PLoS Pathog 4: e1000129 ;
216.	L. Wang, A. Gamez, H. Archer, E. E. Abola, C. N. Sarkissian, P. Fitzpatrick, D. Wendt, Y. Zhang, M. Vellard, J. Bliesath, S. M. Bell, J. F. Lemontt, C. R. Scriver and R. C. Stevens (2008) Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase J Mol Biol 380: 623-35 ;
215.	Q. Zhang, R. Horst, M. Geralt, X. Ma, W. X. Hong, M. G. Finn, R. C. Stevens and K. Wuthrich (2008) Microscale NMR screening of new detergents for membrane protein structural biology J Am Chem Soc 130: 7357-63 ;
214.	M. R. Zurfluh, J. Zschocke, M. Lindner, F. Feillet, C. Chery, A. Burlina, R. C. Stevens, B. Thony and N. Blau (2008) Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency Hum Mutat 29: 1079 ;

Publications - 2007

213.	E. Abola, D. D. Carlton, P. Kuhn and R. C. Stevens (2007) Five years of increasing structural biology throughput. A retrospective analysis H. Jhoti and A. Leach Structure based drug discovery The Netherlands Springer-Verlag 1-26
212.	V. Cherezov, D. M. Rosenbaum, M. A. Hanson, S. G. Rasmussen, F. S. Thian, T. S. Kobilka, H. J. Choi, P. Kuhn, W. I. Weis, B. K. Kobilka and R. C. Stevens (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science 318: 1258-65 ;
211.	A. Gamez, L. Wang, C. N. Sarkissian, D. Wendt, P. Fitzpatrick, J. F. Lemontt, C. R. Scriver and R. C. Stevens (2007) Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria Mol Genet Metab 91: 325-34 ;
210.	C. Garcia-Rodriguez, R. Levy, J. W. Arndt, C. M. Forsyth, A. Razai, J. Lou, I. Geren, R. C. Stevens and J. D. Marks (2007) Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin Nat Biotechnol 25: 107-16 ;
209.	M. A. Hanson, A. Brooun, K. A. Baker, V. P. Jaakola, C. Roth, E. Y. Chien, A. Alexandrov, J. Velasquez, L. Davis, M. Griffith, K. Moy, B. K. Ganser-Pornillos, Y. Hua, P. Kuhn, S. Ellis, M. Yeager and R. C. Stevens (2007) Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression Protein Expr Purif 56: 85-92 ;
208.	J. S. Joseph, K. S. Saikatendu, V. Subramanian, B. W. Neuman, M. J. Buchmeier, R. C. Stevens and P. Kuhn (2007) Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch J Virol 81: 6700-8 ;
207.	D. M. Rosenbaum, V. Cherezov, M. A. Hanson, S. G. Rasmussen, F. S. Thian, T. S. Kobilka, H. J. Choi, X. J. Yao, W. I. Weis, R. C. Stevens and B. K. Kobilka (2007) GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function Science 318: 1266-73 ;
206.	K. S. Saikatendu, J. S. Joseph, V. Subramanian, B. W. Neuman, M. J. Buchmeier, R. C. Stevens and P. Kuhn (2007) Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein J Virol 81: 3913-21 ;
205.	P. Serrano, M. A. Johnson, M. S. Almeida, R. Horst, T. Herrmann, J. S. Joseph, B. W. Neuman, V. Subramanian, K. S. Saikatendu, M. J. Buchmeier, R. C. Stevens, P. Kuhn and K. Wuthrich (2007) Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus J Virol 81: 12049-60 ;
204.	R. C. Stevens (2007) Generation of protein structures for the 21(st) century Structure 15: 1517-9 ;
203.	R. C. Stevens and J. R. Yates, 3rd (2007) You say functional, I say structural J Proteome Res 6: 927 ;
202.	L. Wang, S. Surendran, K. Michals-Matalon, G. Bhatia, S. Tanskley, R. Koch, J. Grady, S. K. Tyring, R. C. Stevens, F. Guttler and R. Matalon (2007) Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin Genet Test 11: 174-8 ;
201.	Q. Zhang, X. Ma, A. Ward, W. X. Hong, V. P. Jaakola, R. C. Stevens, M. G. Finn and G. Chang (2007) Designing facial amphiphiles for the stabilization of integral membrane proteins Angew Chem Int Ed Engl 46: 7023-5 ;

Publications - 2006

200.	E. Abola, P. Kuhn and R. C. Stevens (2006) Miniaturization of the structural biology technologies - from expression to biophysical analyses K. Lundstrom Structural genomics on membrane proteins Boca Raton, Fl. CRC Press 299-320
199.	J. W. Arndt, Q. Chai, T. Christian and R. C. Stevens (2006) Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity Biochemistry 45: 3255-62 ;
198.	J. W. Arndt, M. J. Jacobson, E. E. Abola, C. M. Forsyth, W. H. Tepp, J. D. Marks, E. A. Johnson and R. C. Stevens (2006) A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4 J Mol Biol 362: 733-42 ;
197.	Q. Chai, J. W. Arndt, M. Dong, W. H. Tepp, E. A. Johnson, E. R. Chapman and R. C. Stevens (2006) Structural basis of cell surface receptor recognition by botulinum neurotoxin B Nature 444: 1096-100 ;
196.	M. DiDonato, S. S. Krishna, R. Schwarzenbacher, D. McMullan, S. Agarwalla, S. M. Brittain, M. D. Miller, P. Abdubek, E. Ambing, H. L. Axelrod, J. M. Canaves, H. J. Chiu, A. M. Deacon, L. Duan, M. A. Elsliger, A. Godzik, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, L. Jaroszewski, K. K. Jin, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, A. T. Morse, E. Nigoghossian, L. Okach, S. Oommachen, J. Paulsen, K. Quijano, R. Reyes, C. L. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2006) Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 A resolution reveals a new fold with a novel active site Proteins 65: 771-6 ;
195.	M. DiDonato, S. S. Krishna, R. Schwarzenbacher, D. McMullan, L. Jaroszewski, M. D. Miller, P. Abdubek, S. Agarwalla, E. Ambing, H. Axelrod, T. Biorac, H. J. Chiu, A. M. Deacon, M. A. Elsliger, J. Feuerhelm, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, M. Hornsby, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, K. Moy, E. Nigoghossian, L. Okach, J. Paulsen, K. Quijano, R. Reyes, C. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2006) Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution Proteins 63: 256-60 ;
194.	C. J. Gerdts, V. Tereshko, M. K. Yadav, I. Dementieva, F. Collart, A. Joachimiak, R. C. Stevens, P. Kuhn, A. Kossiakoff and R. F. Ismagilov (2006) Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization Angew Chem Int Ed Engl 45: 8156-60 ;
193.	G. W. Han, S. Sri Krishna, R. Schwarzenbacher, D. McMullan, K. Ginalski, M. A. Elsliger, S. M. Brittain, P. Abdubek, S. Agarwalla, E. Ambing, T. Astakhova, H. Axelrod, J. M. Canaves, H. J. Chiu, M. DiDonato, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, L. Jaroszewski, K. K. Jin, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, M. D. Miller, A. T. Morse, K. Moy, E. Nigoghossian, S. Oommachen, J. Ouyang, J. Paulsen, K. Quijano, R. Reyes, C. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, X. Wang, B. West, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley and I. A. Wilson (2006) Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 A resolution Proteins 64: 1083-90 ;
192.	K. K. Jin, S. S. Krishna, R. Schwarzenbacher, D. McMullan, P. Abdubek, S. Agarwalla, E. Ambing, H. Axelrod, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, J. Feuerhelm, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, M. D. Miller, K. Moy, E. Nigoghossian, L. Okach, S. Oommachen, J. Paulsen, K. Quijano, R. Reyes, C. Rife, R. C. Stevens, G. Spraggon, H. van den Bedem, J. Velasquez, A. White, G. Wolf, G. W. Han, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2006) Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold Proteins 63: 1112-8 ;
191.	J. S. Joseph, K. S. Saikatendu, V. Subramanian, B. W. Neuman, A. Brooun, M. Griffith, K. Moy, M. K. Yadav, J. Velasquez, M. J. Buchmeier, R. C. Stevens and P. Kuhn (2006) Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs J Virol 80: 7894-901 ;
190.	M. Kosloff, G. W. Han, S. S. Krishna, R. Schwarzenbacher, M. Fasnacht, M. A. Elsliger, P. Abdubek, S. Agarwalla, E. Ambing, T. Astakhova, H. L. Axelrod, J. M. Canaves, D. Carlton, H. J. Chiu, T. Clayton, M. DiDonato, L. Duan, J. Feuerhelm, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, L. Jaroszewski, K. K. Jin, H. Johnson, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, I. Levin, D. McMullan, M. D. Miller, A. T. Morse, K. Moy, E. Nigoghossian, L. Okach, S. Oommachen, R. Page, J. Paulsen, K. Quijano, R. Reyes, C. L. Rife, E. Sims, G. Spraggon, V. Sridhar, R. C. Stevens, H. van den Bedem, J. Velasquez, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley and I. A. Wilson (2006) Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution Proteins 65: 527-37 ;
189.	Mathews, II, S. S. Krishna, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, L. Jaroszewski, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, K. Quijano, R. Reyes, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2006) Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution Proteins 63: 1106-11 ;
188.	I. I. Mathews, S. S. Krishna, R. Schwarzenbacher, D. McMullan, L. Jaroszewski, M. D. Miller, P. Abdubek, S. Agarwalla, E. Ambing, H. L. Axelrod, J. M. Canaves, D. Carlton, H. J. Chiu, T. Clayton, M. DiDonato, L. Duan, M. A. Elsliger, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, K. K. Jin, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, I. Levin, A. T. Morse, E. Nigoghossian, L. Okach, S. Oommachen, J. Paulsen, K. Quijano, R. Reyes, C. L. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley and I. A. Wilson (2006) Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution Proteins 65: 249-54 ;
187.	K. Ratia, K. S. Saikatendu, B. D. Santarsiero, N. Barretto, S. C. Baker, R. C. Stevens and A. D. Mesecar (2006) Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme Proc Natl Acad Sci U S A 103: 5717-22 ;
186.	R. Schwarzenbacher, D. McMullan, S. S. Krishna, Q. Xu, M. D. Miller, J. M. Canaves, M. A. Elsliger, R. Floyd, S. K. Grzechnik, L. Jaroszewski, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, T. M. McPhillips, A. T. Morse, K. Quijano, G. Spraggon, R. C. Stevens, H. van den Bedem, G. Wolf, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley and I. A. Wilson (2006) Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold Proteins 65: 243-8 ;
185.	C. R. Scriver, M. Hurtubise, L. Prevost, M. Phommarinh, D. Konecki, H. Erlandsen, R. C. Stevens, P. J. Waters, S. Ryan, D. McDonald and C. N. Sarkissian (2006) A PAH gene knowledgebase: content, informatics, utilization N. Blau PKU and BH4: advances in phenylketonuria and tetrahydrobiopterin research Keilbronn SPS Verlagsgesellschaft 434-451
184.	R. C. Stevens (2006) SPINE Forward Acta Crystallogr D Biol Crystallogr D62: 1 ;
183.	S. Swaminathan and R. C. Stevens (2006) Three dimensional protein structures of botulinum neurotoxin light chains serotypes A, B, and E K. Foster, P. Hambleton and C. Shone Treatments from Toxins: The therapeutic potential of clostridial neurotoxins Boca Raton, Fl. CRC Press
182.	Q. Xu, S. S. Krishna, D. McMullan, R. Schwarzenbacher, M. D. Miller, P. Abdubek, S. Agarwalla, E. Ambing, T. Astakhova, H. L. Axelrod, J. M. Canaves, D. Carlton, H. J. Chiu, T. Clayton, M. DiDonato, L. Duan, M. A. Elsliger, J. Feuerhelm, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, L. Jaroszewski, K. K. Jin, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, A. T. Morse, E. Nigoghossian, L. Okach, S. Oommachen, J. Paulsen, K. Quijano, R. Reyes, C. L. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, A. White, G. Wolf, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley and I. A. Wilson (2006) Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p Proteins 65: 777-82 ;
181.	Q. Xu, R. Schwarzenbacher, S. S. Krishna, D. McMullan, S. Agarwalla, K. Quijano, P. Abdubek, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, M. A. Elsliger, C. Grittini, S. K. Grzechnik, M. DiDonato, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, R. Reyes, C. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, A. White, G. Wolf, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley and I. A. Wilson (2006) Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution Proteins 64: 808-13 ;
180.	Q. Xu, R. Schwarzenbacher, D. McMullan, P. Abdubek, S. Agarwalla, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, K. Quijano, R. Reyes, C. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, A. White, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2006) Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold Proteins 62: 292-6 ;

Publications - 2005

179.	J. W. Arndt, J. Gu, L. Jaroszewski, R. Schwarzenbacher, M. A. Hanson, F. J. Lebeda and R. C. Stevens (2005) The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex J Mol Biol 346: 1083-93 ;
178.	J. W. Arndt, R. Schwarzenbacher, R. Page, P. Abdubek, E. Ambing, T. Biorac, J. M. Canaves, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, L. Jaroszewski, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, E. Nigoghossian, J. Ouyang, W. S. Peti, K. Quijano, R. Reyes, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, A. White, G. Wolf, Q. Xu, O. Zagnitko, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution Proteins 58: 755-8 ;
177.	J. W. Arndt, W. Yu, F. Bi and R. C. Stevens (2005) Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition Biochemistry 44: 9574-80 ;
176.	N. Blau, R. Koch, R. Matalon and R. C. Stevens (2005) Five years of synergistic scientific effort on phenylketonuria therapeutic development and molecular understanding Mol Genet Metab 86 Suppl 1: 1 ;
175.	D. C. Carter, P. Rhodes, D. E. McRee, L. Tari, D. R. Dougan, G. Snell, E. Abola and R. C. Stevens (2005) Reduction in diffuse-convective disturbances in nanovolume protein crystallization experiments J Appl Crystallogr 38: 87-90 ;
174.	J. S. Chappie, J. M. Canaves, G. W. Han, C. L. Rife, Q. Xu and R. C. Stevens (2005) The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases Structure 13: 1385-96 ;
173.	B. Collins, R. C. Stevens and R. Page (2005) Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation Acta Crystallogr Sect F Struct Biol Cryst Commun 61: 1035-8 ;
172.	A. Gamez, C. N. Sarkissian, L. Wang, W. Kim, M. Straub, M. G. Patch, L. Chen, S. Striepeke, P. Fitzpatrick, J. F. Lemontt, C. O'Neill, C. R. Scriver and R. C. Stevens (2005) Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria Mol Ther 11: 986-9 ;
171.	G. W. Han, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, T. M. McPhillips, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, K. Quijano, R. Reyes, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution Proteins 60: 797-802 ;
170.	G. W. Han, R. Schwarzenbacher, R. Page, L. Jaroszewski, P. Abdubek, E. Ambing, T. Biorac, J. M. Canaves, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, J. Haugen, M. Hornsby, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, E. Nigoghossian, J. Ouyang, J. Paulsen, K. Quijano, R. Reyes, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, A. White, G. Wolf, Q. Xu, O. Zagnitko, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor Proteins 58: 971-5 ;
169.	L. Jaroszewski, R. Schwarzenbacher, D. McMullan, P. Abdubek, S. Agarwalla, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, K. Quijano, R. Reyes, C. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution Proteins 61: 669-73 ;
168.	H. E. Klock, R. Schwarzenbacher, Q. Xu, D. McMullan, P. Abdubek, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, E. Koesema, A. Kreusch, P. Kuhn, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, K. Quijano, R. Reyes, C. Rife, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, A. White, G. Wolf, K. O. Hodgson, J. Wooley, S. A. Lesley and I. A. Wilson (2005) Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold Proteins 61: 1132-6 ;
167.	I. Levin, M. D. Miller, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, T. Biorac, J. Cambell, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, A. Morse, K. Moy, E. Nigoghossian, J. Ouyang, R. Page, K. Quijano, R. Reyes, A. Robb, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, O. Zagnitko, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold Proteins 59: 864-8 ;
166.	R. Matalon, K. Michals-Matalon, R. Koch, J. Grady, S. Tyring and R. C. Stevens (2005) Response of patients with phenylketonuria in the US to tetrahydrobiopterin Mol Genet Metab 86 Suppl 1: S17-21 ;
165.	I. I. Mathews, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, M. D. Miller, K. Moy, E. Nigoghossian, J. Ouyang, J. Paulsen, K. Quijano, R. Reyes, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold Proteins 59: 869-74 ;
164.	R. Page, A. M. Deacon, S. A. Lesley and R. C. Stevens (2005) Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins J Struct Funct Genomics 6: 209-17 ;
163.	R. Page, W. Peti, I. A. Wilson, R. C. Stevens and K. Wuthrich (2005) NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline Proc Natl Acad Sci U S A 102: 1901-5 ;
162.	B. Perez, L. R. Desviat, P. Gomez-Puertas, A. Martinez, R. C. Stevens and M. Ugarte (2005) Kinetic and stability analysis of PKU mutations identified in BH4-responsive patients Mol Genet Metab 86 Suppl 1: S11-6 ;
161.	W. Peti, M. A. Johnson, T. Herrmann, B. W. Neuman, M. J. Buchmeier, M. Nelson, J. Joseph, R. Page, R. C. Stevens, P. Kuhn and K. Wuthrich (2005) Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7 J Virol 79: 12905-13 ;
160.	W. Peti, R. Page, K. Moy, M. O'Neil-Johnson, I. A. Wilson, R. C. Stevens and K. Wuthrich (2005) Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR J Struct Funct Genomics 6: 259-67 ;
159.	J. S. Ricci, R. C. Stevens, R. K. McMullan and W. T. Klooster (2005) Structure of strontium hydroxide octahydrate, Sr(OH)2.8H2O, at 20, 100 and 200 K from neutron diffraction Acta Crystallogr B 61: 381-6 ;
158.	C. Rife, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, K. Quijano, R. Reyes, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold Proteins 61: 444-8 ;
157.	C. Rife, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H. J. Chiu, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, K. Quijano, R. Reyes, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, A. White, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold Proteins 61: 449-53 ;
156.	K. S. Saikatendu, J. S. Joseph, V. Subramanian, T. Clayton, M. Griffith, K. Moy, J. Velasquez, B. W. Neuman, M. J. Buchmeier, R. C. Stevens and P. Kuhn (2005) Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3 Structure 13: 1665-75 ;
155.	L. Wang, A. Gamez, C. N. Sarkissian, M. Straub, M. G. Patch, G. W. Han, S. Striepeke, P. Fitzpatrick, C. R. Scriver and R. C. Stevens (2005) Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria Mol Genet Metab 86: 134-40 ;
154.	Q. Xu, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, T. Biorac, J. M. Canaves, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, M. Hornsby, L. Jaroszewski, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, R. Reyes, A. Robb, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, A. White, G. Wolf, O. Zagnitko, K. O. Hodgson, J. Wooley and I. A. Wilson (2005) Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold Proteins 58: 976-81 ;
153.	M. K. Yadav, C. J. Gerdts, R. Sanishvili, W. W. Smith, L. S. Roach, R. F. Ismagilov, P. Kuhn and R. C. Stevens (2005) In situ data collection and structure refinement from microcapillary protein crystallization J Appl Crystallogr 38: 900-905 ;

Publications - 2004

152.	C. Bakolitsa, R. Schwarzenbacher, D. McMullan, L. S. Brinen, J. M. Canaves, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold Proteins 56: 607-10 ;
151.	M. Bern, D. Goldberg, R. C. Stevens and P. Kuhn (2004) Automatic classification of protein crystallization images using a curve tracking algorithm J Appl Crystallogr 37: 279-287 ;
150.	M. H. Bracey, B. F. Cravatt and R. C. Stevens (2004) Structural commonalities among integral membrane enzymes FEBS Lett 567: 159-65 ;
149.	J. M. Canaves, R. Page, I. A. Wilson and R. C. Stevens (2004) Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics J Mol Biol 344: 977-91 ;
148.	H. Erlandsen, J. M. Canaves, M. A. Elsliger, F. von Delft, L. S. Brinen, X. Dai, A. M. Deacon, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, L. Jaroszewski, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, A. Robb, K. Quijano, R. Schwarzenbacher, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution Proteins 54: 806-9 ;
147.	H. Erlandsen, A. L. Pey, A. Gamez, B. Perez, L. R. Desviat, C. Aguado, R. Koch, S. Surendran, S. Tyring, R. Matalon, C. R. Scriver, M. Ugarte, A. Martinez and R. C. Stevens (2004) Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations Proc Natl Acad Sci U S A 101: 16903-8 ;
146.	A. Gamez, L. Wang, M. Straub, M. G. Patch and R. C. Stevens (2004) Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase Mol Ther 9: 124-9 ;
145.	A. Heine, J. M. Canaves, F. von Delft, L. S. Brinen, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshaghi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, C. Guda, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. A. Miller, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, A. Robb, K. Rodrigues, R. Schwarzenbacher, T. L. Selby, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution Proteins 56: 387-91 ;
144.	L. Jaroszewski, R. Schwarzenbacher, F. von Delft, D. McMullan, L. S. Brinen, J. M. Canaves, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, I. Levin, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, R. Reyes, F. Rezezadeh, A. Robb, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution Proteins 56: 611-4 ;
143.	W. Kim, H. Erlandsen, S. Surendran, R. C. Stevens, A. Gamez, K. Michols-Matalon, S. K. Tyring and R. Matalon (2004) Trends in enzyme therapy for phenylketonuria Mol Ther 10: 220-4 ;
142.	I. Levin, R. Schwarzenbacher, D. McMullan, P. Abdubek, E. Ambing, T. Biorac, J. Cambell, J. M. Canaves, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, A. Kreusch, P. Kuhn, S. A. Lesley, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, R. Reyes, A. Robb, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution Proteins 56: 629-33 ;
141.	I. Levin, R. Schwarzenbacher, R. Page, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. Campbell, J. M. Canaves, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, K. Quijano, R. Reyes, F. Rezezadeh, A. Robb, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution Proteins 56: 404-8 ;
140.	R. Matalon, R. Koch, K. Michals-Matalon, K. Moseley, S. Surendran, S. Tyring, H. Erlandsen, A. Gamez, R. C. Stevens, A. Romstad, L. B. Moller and F. Guttler (2004) Biopterin responsive phenylalanine hydroxylase deficiency Genet Med 6: 27-32 ;
139.	D. McMullan, R. Schwarzenbacher, L. Jaroszewski, F. von Delft, H. E. Klock, J. Vincent, K. Quijano, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshaghi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, C. Karlak, E. Koesema, A. Kreusch, P. Kuhn, I. Levin, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, R. Reyes, F. Rezezadeh, A. Robb, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley, S. A. Lesley and I. A. Wilson (2004) Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution Proteins 56: 615-8 ;
138.	M. D. Miller, R. Schwarzenbacher, F. von Delft, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution Proteins 57: 213-7 ;
137.	R. Page, K. Moy, E. C. Sims, J. Velasquez, B. McManus, C. Grittini, T. L. Clayton and R. C. Stevens (2004) Scalable high-throughput micro-expression device for recombinant proteins Biotechniques 37: 364, 366, 368 passim ;
136.	R. Page, M. S. Nelson, F. von Delft, M. A. Elsliger, J. M. Canaves, L. S. Brinen, X. Dai, A. M. Deacon, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, L. Jaroszewski, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, A. Robb, K. Rodrigues, R. Schwarzenbacher, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution Proteins 54: 157-61 ;
135.	R. Page and R. C. Stevens (2004) Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens Methods 34: 373-89 ;
134.	D. Pantazatos, J. S. Kim, H. E. Klock, R. C. Stevens, I. A. Wilson, S. A. Lesley and V. L. Woods, Jr. (2004) Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS Proc Natl Acad Sci U S A 101: 751-6 ;
133.	A. L. Pey, B. Perez, L. R. Desviat, M. A. Martinez, C. Aguado, H. Erlandsen, A. Gamez, R. C. Stevens, M. Thorolfsson, M. Ugarte and A. Martinez (2004) Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations Hum Mutat 24: 388-99 ;
132.	A. L. Pey, M. Thorolfsson, H. Erlandsen, R. C. Stevens, M. Ugarte, L. R. Desviat, B. Perez and A. Martinez (2004) Thermodynamic parameters for the binding of tetrahydrobiopterin to human phenylalanine hydroxylase N. Blau and B. Thony Pterins, Folates & Neurotransmitters Mol. Med. Heilbronn, Germany SPS Verlagsgesellschaft mbH 155-160
131.	E. Santelli, R. Schwarzenbacher, D. McMullan, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, F. Rezezadeh, A. Robb, E. Sims, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution Proteins 56: 167-70 ;
130.	R. Schwarzenbacher, A. M. Deacon, L. Jaroszewski, L. S. Brinen, J. M. Canaves, X. Dai, M. A. Elsliger, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, M. S. Nelson, J. Ouyang, R. Page, A. Robb, K. Quijano, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution Proteins 54: 801-5 ;
129.	R. Schwarzenbacher, L. Jaroszewski, F. von Delft, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution Proteins 55: 768-71 ;
128.	R. Schwarzenbacher, L. Jaroszewski, F. von Delft, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution Proteins 55: 759-63 ;
127.	R. Schwarzenbacher, L. Jaroszewski, F. von Delft, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution Proteins 55: 474-8 ;
126.	R. Schwarzenbacher, F. von Delft, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution Proteins 54: 810-3 ;
125.	R. Schwarzenbacher, F. von Delft, J. M. Canaves, L. S. Brinen, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshaghi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, C. Guda, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. A. Miller, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, A. Robb, K. Rodrigues, T. L. Selby, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution Proteins 54: 174-7 ;
124.	R. Schwarzenbacher, F. von Delft, L. Jaroszewski, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution Proteins 56: 392-5 ;
123.	Z. Shen, E. P. Go, A. Gamez, J. V. Apon, V. Fokin, M. Greig, M. Ventura, J. E. Crowell, O. Blixt, J. C. Paulson, R. C. Stevens, M. G. Finn and G. Siuzdak (2004) A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform Chembiochem 5: 921-7 ;
122.	G. Snell, C. Cork, R. Nordmeyer, E. Cornell, G. Meigs, D. Yegian, J. Jaklevic, J. Jin, R. C. Stevens and T. Earnest (2004) Automated sample mounting and alignment system for biological crystallography at a synchrotron source Structure 12: 537-45 ;
121.	J. Song, R. C. Stevens and Q. Cheng (2004) Functional amphiphilic and bolaamphiphilic poly(diacetylene) assemblies with controlled optical and morphological properties S. A. Jenekhe and D. J. Kiserow Chromogenic Phenomena in Polymers: Tunable Optical Properties Oxford Amer Chem Soc
120.	G. Spraggon, R. Schwarzenbacher, A. Kreusch, C. C. Lee, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. M. Canaves, J. Cambell, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, P. Kuhn, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley, S. A. Lesley and I. A. Wilson (2004) Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution Proteins 55: 1078-81 ;
119.	G. Spraggon, R. Schwarzenbacher, A. Kreusch, D. McMullan, L. S. Brinen, J. M. Canaves, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, P. Kuhn, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, F. Rezezadeh, A. Robb, E. Sims, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, Q. Xu, K. O. Hodgson, J. Wooley, S. A. Lesley and I. A. Wilson (2004) Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution Proteins 56: 396-400 ;
118.	R. C. Stevens (2004) Long live structural biology Nat Struct Mol Biol 11: 293-5 ;
117.	Q. Xu, R. Schwarzenbacher, D. McMullan, F. von Delft, L. S. Brinen, J. M. Canaves, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshagi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, R. Page, K. Quijano, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution Proteins 56: 171-5 ;
116.	Q. Xu, R. Schwarzenbacher, R. Page, E. Sims, P. Abdubek, E. Ambing, T. Biorac, L. S. Brinen, J. Cambell, J. M. Canaves, H. J. Chiu, X. Dai, A. M. Deacon, M. DiDonato, M. A. Elsliger, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, E. Hampton, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, I. Levin, D. McMullan, T. M. McPhillips, M. D. Miller, A. Morse, K. Moy, J. Ouyang, K. Quijano, R. Reyes, F. Rezezadeh, A. Robb, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, F. von Delft, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2004) Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution Proteins 56: 619-24 ;

Publications - 2003

115.	L. S. Brinen, J. M. Canaves, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshaghi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, C. Guda, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. A. Miller, M. D. Miller, A. Morse, K. Moy, J. Ouyang, A. Robb, K. Rodrigues, T. L. Selby, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, S. S. Taylor, K. O. Hodgson, J. Wooley and I. A. Wilson (2003) Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution Proteins 50: 371-4 ;
114.	H. Erlandsen, M. G. Patch, A. Gamez, M. Straub and R. C. Stevens (2003) Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria Pediatrics 112: 1557-65 ;
113.	D. Hosfield, J. Palan, M. Hilgers, D. Scheibe, D. E. McRee and R. C. Stevens (2003) A fully integrated protein crystallization platform for small-molecule drug discovery J Struct Biol 142: 207-17 ;
112.	R. Page, S. K. Grzechnik, J. M. Canaves, G. Spraggon, A. Kreusch, P. Kuhn, R. C. Stevens and S. A. Lesley (2003) Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome Acta Crystallogr D Biol Crystallogr 59: 1028-37 ;
111.	R. Schwarzenbacher, J. M. Canaves, L. S. Brinen, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshaghi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, C. Guda, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. S. Kovarik, A. Kreusch, P. Kuhn, S. A. Lesley, D. McMullan, T. M. McPhillips, M. A. Miller, M. D. Miller, A. Morse, K. Moy, J. Ouyang, A. Robb, K. Rodrigues, T. L. Selby, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, K. O. Hodgson, J. Wooley and I. A. Wilson (2003) Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution Proteins 53: 142-5 ;
110.	C. R. Scriver, M. Hurtubise, D. Konecki, M. Phommarinh, L. Prevost, H. Erlandsen, R. C. Stevens, P. J. Waters, S. Ryan, D. McDonald and C. N. Sarkissian (2003) PAHdb 2003: What a locus-specific knowledgebase can do Hum Mutat 21: 333-344 ;
109.	R. C. Stevens (2003) The cost and value of three-dimensional protein structure Drug Disc World 4: 35-48 ;
108.	M. Weselak, M. G. Patch, T. L. Selby, G. Knebel and R. C. Stevens (2003) Robotics for automated crystal formation and analysis Methods Enzymol 368: 45-76 ;
107.	J. Yin, S. E. Andryski, A. E. t. Beuscher, R. C. Stevens and P. G. Schultz (2003) Structural evidence for substrate strain in antibody catalysis Proc Natl Acad Sci U S A 100: 856-61 ;
106.	J. Yin, A. E. t. Beuscher, S. E. Andryski, R. C. Stevens and P. G. Schultz (2003) Structural plasticity and the evolution of antibody affinity and specificity J Mol Biol 330: 651-6 ;

Publications - 2002

105.	M. H. Bracey, M. A. Hanson, K. R. Masuda, R. C. Stevens and B. F. Cravatt (2002) Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling Science 298: 1793-6 ;
104.	Q. Cheng and R. C. Stevens (2002) Smart” materials for colorimetric detection of pathogenic agents W. T. Law, N. Akmal and A. M. Usmani Biomedical Diagnostic Science and Technology New York Marcel Dekker 291-305
103.	H. Erlandsen, J. Y. Kim, M. G. Patch, A. Han, A. Volner, M. M. Abu-Omar and R. C. Stevens (2002) Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates J Mol Biol 320: 645-61 ;
102.	H. L. Grossman, S. Lee, W. Myers, Y. R. Chemla, Y. Poon, H. M. Cho, R. McDermott, R. C. Stevens, M. D. Alper and J. Clarke (2002) Superconducting quantum interference device detection of magnetically tagged micro-organisms Proc SPIE Internatl Soc Optical Engineer 4576: 122-125 ;
101.	M. A. Hanson and R. C. Stevens (2002) Structural view of botulinum neurotoxin in numerous functional states M. Brin, J. Jankovic and M. Hallett Scientific and Therapeutic Aspects of Botulinum Toxin Philadelphia Lippincott, Williams & Wilkins 11-27
100.	P. Kuhn, S. A. Lesley, Mathews, II, J. M. Canaves, L. S. Brinen, X. Dai, A. M. Deacon, M. A. Elsliger, S. Eshaghi, R. Floyd, A. Godzik, C. Grittini, S. K. Grzechnik, C. Guda, K. O. Hodgson, L. Jaroszewski, C. Karlak, H. E. Klock, E. Koesema, J. M. Kovarik, A. T. Kreusch, D. McMullan, T. M. McPhillips, M. A. Miller, M. Miller, A. Morse, K. Moy, J. Ouyang, A. Robb, K. Rodrigues, T. L. Selby, G. Spraggon, R. C. Stevens, S. S. Taylor, H. van den Bedem, J. Velasquez, J. Vincent, X. Wang, B. West, G. Wolf, J. Wooley and I. A. Wilson (2002) Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution Proteins 49: 142-5 ;
99.	P. Kuhn, K. Wilson, M. G. Patch and R. C. Stevens (2002) The genesis of high-throughput structure-based drug discovery using protein crystallography Curr Opin Chem Biol 6: 704-10 ;
98.	S. A. Lesley, P. Kuhn, A. Godzik, A. M. Deacon, I. Mathews, A. Kreusch, G. Spraggon, H. E. Klock, D. McMullan, T. Shin, J. Vincent, A. Robb, L. S. Brinen, M. D. Miller, T. M. McPhillips, M. A. Miller, D. Scheibe, J. M. Canaves, C. Guda, L. Jaroszewski, T. L. Selby, M. A. Elsliger, J. Wooley, S. S. Taylor, K. O. Hodgson, I. A. Wilson, P. G. Schultz and R. C. Stevens (2002) Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline Proc Natl Acad Sci U S A 99: 11664-9 ;
97.	B. D. Santarsiero, D. T. Yegian, C. C. Lee, G. Spraggon, J. Gu, D. Scheibe, D. C. Uber, E. W. Cornell, R. A. Nordmeyer, W. F. Kolbe, J. Jin, A. L. Jones, J. M. Jaklevic, P. G. Schultz and R. C. Stevens (2002) An approach to rapid protein crystallization using nanodroplets J Appl Crystallogr 35: 278-281 ;
96.	T. L. Selby and R. C. Stevens (2002) Bioinformatics and high-throughput protein production for structural genomics M. P. Weiner and Q. Lu Gene Cloning and Expression Technologies Westborough, MA Biotechniques Press 281-304
95.	J. Song, Q. Cheng and R. C. Stevens (2002) Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping Chem Phys Lipids 114: 203-14 ;
94.	J. Song, Q. Cheng, S. Zhu and R. C. Stevens (2002) "Smart" materials for biosensing devices: Cell-mimicking supramolecular assemblies and colorimetric detection of pathogenic agents Biomed Microdevices 4: 213-221 ;
93.	L. Wang, H. Erlandsen, J. Haavik, P. M. Knappskog and R. C. Stevens (2002) Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry 41: 12569-74 ;

Publications - 2001

92.	D. W. Chen, A. E. t. Beuscher, R. C. Stevens, P. Wirsching, R. A. Lerner and K. D. Janda (2001) Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies J Org Chem 66: 1725-32 ;
91.	H. Erlandsen and R. C. Stevens (2001) A structural hypothesis for BH4 responsiveness in patients with mild forms of hyperphenylalaninaemia and phenylketonuria J Inherit Metab Dis 24: 213-30 ;
90.	K. E. Goodwill, M. G. Tennant and R. C. Stevens (2001) High-throughput X-ray crystallography for structure-based drug design Drug Disc Today 6: S113-S118 ;
89.	M. C. Orencia, J. S. Yoon, J. E. Ness, W. P. Stemmer and R. C. Stevens (2001) Predicting the emergence of antibiotic resistance by directed evolution and structural analysis Nat Struct Biol 8: 238-42 ;
88.	O. Rossetto, P. Caccin, M. Rigoni, F. Tonello, N. Bortoletto, R. C. Stevens and C. Montecucco (2001) Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity Toxicon 39: 1151-9 ;
87.	J. Song, Q. Cheng, S. Kopta and R. C. Stevens (2001) Modulating artificial membrane morphology: pH-induced chromatic transition and nanostructural transformation of a bolaamphiphilic conjugated polymer from blue helical ribbons to red nanofibers J Am Chem Soc 123: 3205-13 ;
86.	R. C. Stevens and I. A. Wilson (2001) Tech.Sight. Industrializing structural biology Science 293: 519-20 ;
85.	R. C. Stevens, S. Yokoyama and I. A. Wilson (2001) Global efforts in structural genomics Science 294: 89-92 ;
84.	J. Yin, E. C. Mundorff, P. L. Yang, K. U. Wendt, D. Hanway, R. C. Stevens and P. G. Schultz (2001) A comparative analysis of the immunological evolution of antibody 28B4 Biochemistry 40: 10764-73 ;

Publications - 2000

83.	E. Abola, P. Kuhn, T. Earnest and R. C. Stevens (2000) Automation of X-ray crystallography Nat Struct Biol 7 Suppl: 973-7 ;
82.	M. G. Baek, R. C. Stevens and D. H. Charych (2000) Design and synthesis of novel glycopolythiophene assemblies for colorimetric detection of influenza virus and E. coli Bioconjug Chem 11: 777-88 ;
81.	Y. R. Chemla, H. L. Grossman, Y. Poon, R. McDermott, R. Stevens, M. D. Alper and J. Clarke (2000) Ultrasensitive magnetic biosensor for homogeneous immunoassay Proc Natl Acad Sci U S A 97: 14268-72 ;
80.	Q. Cheng, M. Yamamoto and R. Stevens (2000) Amino acid terminated polydiacetylene lipid microstructures: morphology and chromatic transition Langmuir 16: 5333-5342 ;
79.	H. Erlandsen, E. E. Abola and R. C. Stevens (2000) Combining structural genomics and enzymology: completing the picture in metabolic pathways and enzyme active sites Curr Opin Struct Biol 10: 719-30 ;
78.	H. Erlandsen, E. Bjorgo, T. Flatmark and R. C. Stevens (2000) Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase Biochemistry 39: 2208-17 ;
77.	T. Flatmark, H. Erlandsen, E. Bjorgo, T. Solstad, A. P. Doskeland and R. C. Stevens (2000) Regulatory properties of tetrahydrobiopterin cofactor bound at the active site of phenylalanine hydroxylase Pteridines 11: 34-36 ;
76.	M. A. Hanson and R. C. Stevens (2000) Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution Nat Struct Biol 7: 687-92 ;
75.	E. C. Mundorff, M. A. Hanson, A. Varvak, H. Ulrich, P. G. Schultz and R. C. Stevens (2000) Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement Biochemistry 39: 627-32 ;
74.	M. C. Orencia, M. A. Hanson and R. C. Stevens (2000) Structural analysis of affinity matured antibodies and laboratory-evolved enzymes Adv Protein Chem 55: 227-59 ;
73.	T. Peng, Q. Cheng and R. C. Stevens (2000) Amperometric detection of Escherichia coli heat-labile enterotoxin by redox diacetylenic vesicles on a sol-gel thin-film electrode Anal Chem 72: 1611-7 ;
72.	J. P. Rogers, P. Luginbuhl, K. Pemberton, P. Harty, D. E. Wemmer and R. C. Stevens (2000) Structure-activity relationships in a peptidic alpha7 nicotinic acetylcholine receptor antagonist J Mol Biol 304: 911-26 ;
71.	A. Simeonov, M. Matsushita, E. A. Juban, E. H. Thompson, T. Z. Hoffman, A. E. t. Beuscher, M. J. Taylor, P. Wirsching, W. Rettig, J. K. McCusker, R. C. Stevens, D. P. Millar, P. G. Schultz, R. A. Lerner and K. D. Janda (2000) Blue-fluorescent antibodies Science 290: 307-13 ;
70.	R. C. Stevens (2000) High-throughput protein crystallization Curr Opin Struct Biol 10: 558-63 ;
69.	R. C. Stevens (2000) Design of high-throughput methods of protein production for structural biology Structure 8: R177-85 ;

Publications - 1999

68.	Q. Cheng, J. A. Fu, R. Burkard, W. Wang, M. Yamamoto, J. Yang and R. C. Stevens (1999) Monolayer and epi-flourescence microscopy studies of amino acid derivatized diacetylene lipids Thin Solid Films 345: 292-299 ;
67.	Q. Cheng, T. Peng and R. C. Stevens (1999) Signaling of Escherichia coli enterotoxin on supramolecular redox bilayer vesicles J Am Chem Soc 121: 6767-6768 ;
66.	H. Erlandsen and R. C. Stevens (1999) The structural basis of phenylketonuria Mol Genet Metab 68: 103-25 ;
65.	T. Flatmark and R. C. Stevens (1999) Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms Chem Rev 99: 2137-2160 ;
64.	B. Kobe, I. G. Jennings, C. M. House, B. J. Michell, K. E. Goodwill, B. D. Santarsiero, R. C. Stevens, R. G. Cotton and B. E. Kemp (1999) Structural basis of autoregulation of phenylalanine hydroxylase Nat Struct Biol 6: 442-8 ;
63.	D. B. Lacy and R. C. Stevens (1999) Sequence homology and structural analysis of the clostridial neurotoxins J Mol Biol 291: 1091-104 ;
62.	J. P. Rogers, P. Luginbuhl, G. S. Shen, R. T. McCabe, R. C. Stevens and D. E. Wemmer (1999) NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors Biochemistry 38: 3874-82 ;
61.	B. Spiller, A. Gershenson, F. H. Arnold and R. C. Stevens (1999) A structural view of evolutionary divergence Proc Natl Acad Sci U S A 96: 12305-10 ;

Publications - 1998

60.	B. Andersen and R. C. Stevens (1998) The human D1A dopamine receptor: heterologous expression in Saccharomyces cerevisiae and purification of the functional receptor Protein Expr Purif 13: 111-9 ;
59.	E. Bjorgo, P. M. Knappskog, A. Martinez, R. C. Stevens and T. Flatmark (1998) Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria Eur J Biochem 257: 1-10 ;
58.	F. Chen, G. M. Kuziemko and R. C. Stevens (1998) Biophysical characterization of the stability of the 150-kilodalton botulinum toxin, the nontoxic component, and the 900-kilodalton botulinum toxin complex species Infect Immun 66: 2420-5 ;
57.	Q. Cheng and R. C. Stevens (1998) Charge-induced chromatic transition of amino acid-derivatized polydiacetylene liposomes Langmuir 14: 1974-1976 ;
56.	H. Erlandsen, T. Flatmark, R. C. Stevens and E. Hough (1998) Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution Biochemistry 37: 15638-46 ;
55.	F. Fusetti, H. Erlandsen, T. Flatmark and R. C. Stevens (1998) Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria J Biol Chem 273: 16962-7 ;
54.	K. E. Goodwill, C. Sabatier and R. C. Stevens (1998) Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site Biochemistry 37: 13437-45 ;
53.	C. U. Kim, W. Lew, M. A. Williams, H. Wu, L. Zhang, X. Chen, P. A. Escarpe, D. B. Mendel, W. G. Laver and R. C. Stevens (1998) Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors J Med Chem 41: 2451-60 ;
52.	D. B. Lacy and R. C. Stevens (1998) Unraveling the structures and modes of action of bacterial toxins Curr Opin Struct Biol 8: 778-84 ;
51.	D. B. Lacy, W. Tepp, A. C. Cohen, B. R. DasGupta and R. C. Stevens (1998) Crystal structure of botulinum neurotoxin type A and implications for toxicity Nat Struct Biol 5: 898-902 ;
50.	R. J. Lagow, J. J. Kampa, H. C. Wei, S. L. Battle, J. W. Genge, D. A. Laude, C. J. Harper, D. R. Mitchell, R. Bau, R. C. Stevens, J. F. Haw and E. Munson (1998) Synthesis of linear acetylenic carbon; the fourth carbon allotrope Tanso 81: 27 ;
49.	F. E. Romesberg, B. D. Santarsiero, B. Spiller, J. Yin, D. Barnes, P. G. Schultz and R. C. Stevens (1998) Structural and kinetic evidence for strain in biological catalysis Biochemistry 37: 14404-9 ;
48.	F. E. Romesberg, B. Spiller, P. G. Schultz and R. C. Stevens (1998) Immunological origins of binding and catalysis in a Diels-Alderase antibody Science 279: 1929-33 ;

Publications - 1997

47.	F. Burkard, F. Chen, G. M. Kuziemko and R. C. Stevens (1997) Electron density projection map of the botulinum neurotoxin 900-kilodalton complex by electron crystallography J Struct Biol 120: 78-84 ;
46.	F. Chen, G. M. Kuziemko, P. Amersdorfer, C. Wong, J. D. Marks and R. C. Stevens (1997) Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms Infect Immun 65: 1626-30 ;
45.	Q. Cheng and R. C. Stevens (1997) Coupling of an induced fit enzyme to polydiacetylene thin films: Colorimetric detection of glucose Advanced Materials 9: 481-483 ;
44.	Q. Cheng and R. C. Stevens (1997) Monolayer properties of monosailioganglioside in the mixed diacetylene lipid films on the air/water interface Chem Phys Lipids 87: 41-53 ;
43.	N. E. David, M. Gee, B. Andersen, F. Naider, J. Thorner and R. C. Stevens (1997) Expression and purification of the Saccharomyces cerevisiae alpha-factor receptor (Ste2p), a 7-transmembrane-segment G protein-coupled receptor J Biol Chem 272: 15553-61 ;
42.	H. Erlandsen, F. Fusetti, A. Martinez, E. Hough, T. Flatmark and R. C. Stevens (1997) Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria Nat Struct Biol 4: 995-1000 ;
41.	K. E. Goodwill, C. Sabatier, C. Marks, R. Raag, P. F. Fitzpatrick and R. C. Stevens (1997) Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases Nat Struct Biol 4: 578-85 ;
40.	C. U. Kim, W. Lew, M. A. Williams, H. Liu, L. Zhang, S. Swaminathan, N. Bischofberger, M. S. Chen, D. B. Mendel, C. Y. Tai, W. G. Laver and R. C. Stevens (1997) Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity J Am Chem Soc 119: 681-90 ;
39.	D. B. Lacy and R. C. Stevens (1997) Recombinant expression and purification of the botulinum neurotoxin type A translocation domain Protein Expr Purif 11: 195-200 ;
38.	H. D. Ulrich, E. Mundorff, B. D. Santarsiero, E. M. Driggers, R. C. Stevens and P. G. Schultz (1997) The interplay between binding energy and catalysis in the evolution of a catalytic antibody Nature 389: 271-5 ;
37.	G. J. Wedemayer, P. A. Patten, L. H. Wang, P. G. Schultz and R. C. Stevens (1997) Structural insights into the evolution of an antibody combining site Science 276: 1665-9 ;
36.	G. J. Wedemayer, L. H. Wang, P. A. Patten, P. G. Schultz and R. C. Stevens (1997) Crystal structures of the free and liganded form of an esterolytic catalytic antibody J Mol Biol 268: 390-400 ;
35.	M. A. Williams, W. Lew, D. B. Mendel, C. Y. Tai, P. A. Escarpe, W. G. Laver, R. C. Stevens and C. U. Kim (1997) Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors Bioorg Med Chem Lett 7: 1837-1842 ;

Publications - 1996

34.	D. Charych, Q. Cheng, A. Reichert, G. Kuziemko, M. Stroh, J. O. Nagy, W. Spevak and R. C. Stevens (1996) A 'litmus test' for molecular recognition using artificial membranes Chem Biol 3: 113-20 ;
33.	K. E. Goodwill, E. Gamlund, B. D. Santarsiero and R. C. Stevens (1996) Design of an inverted spindle axis for frozen crystal screening and storage J Appl Crystallogr 29: 738-740 ;
32.	L. C. Hsieh-Wilson, P. G. Schultz and R. C. Stevens (1996) Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution Proc Natl Acad Sci U S A 93: 5363-7 ;
31.	G. M. Kuziemko, M. Stroh and R. C. Stevens (1996) Cholera toxin binding affinity and specificity for gangliosides determined by surface plasmon resonance Biochemistry 35: 6375-84 ;
30.	P. A. Patten, N. S. Gray, P. L. Yang, C. B. Marks, G. J. Wedemayer, J. J. Boniface, R. C. Stevens and P. G. Schultz (1996) The immunological evolution of catalysis Science 271: 1086-91 ;
29.	R. C. Stevens, L. C. Hsieh-Wilson, B. D. Santarsiero, G. J. Wedemayer, B. Spiller, L. H. Wang, D. Barnes, H. Ulrich, P. A. Patten, F. E. Romesberg and P. G. Schultz (1996) Structural studies of catalytic antibodies Israel J Chem 36: 121-132 ;

Publications - 1995

28.	R. J. Lagow, J. J. Kampa, H. C. Wei, S. L. Battle, J. W. Genge, D. A. Laude, C. J. Harper, R. Bau, R. C. Stevens, J. F. Haw and E. Munson (1995) Synthesis of Linear Acetylenic Carbon: The "sp" Carbon Allotrope Science 267: 362-367 ;

Publications - 1994

27.	H. S. Yuan, R. C. Stevens, R. Bau, H. S. Mosher and T. F. Koetzle (1994) Determination of the absolute configuration of (+)-neopentyl-1-d alcohol by neutron and x-ray diffraction analysis Proc Natl Acad Sci U S A 91: 12872-6 ;

Publications - 1993

26.	R. C. Stevens (1993) Low-resolution model of botulinum neurotoxin B. DasGupta Botulinum neurotoxin Plenum Publishing Co.
25.	R. C. Stevens and W. N. Lipscomb (1993) Allosteric enzymes F. Diamond, T. F. Koetzle, K. Prout and J. S. Richardson Molecular Structures in Biology New York Oxford University Press 222-259

Publications - 1992

24.	C. J. Newton, R. C. Stevens and E. R. Kantrowitz (1992) Importance of a conserved residue, aspartate-162, for the function of Escherichia coli aspartate transcarbamoylase Biochemistry 31: 3026-32 ;
23.	J. W. Stebbins, D. E. Robertson, M. F. Roberts, R. C. Stevens, W. N. Lipscomb and E. R. Kantrowitz (1992) Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study Protein Sci 1: 1435-46 ;
22.	R. C. Stevens and W. N. Lipscomb (1992) A molecular mechanism for pyrimidine and purine nucleotide control of aspartate transcarbamoylase Proc Natl Acad Sci U S A 89: 5281-5 ;

Publications - 1991

21.	R. C. Stevens, Y. M. Chook, C. Y. Cho, W. N. Lipscomb and E. R. Kantrowitz (1991) Escherichia coli aspartate carbamoyltransferase: the probing of crystal structure analysis via site-specific mutagenesis Protein Eng 4: 391-408 ;
20.	R. C. Stevens, M. L. Evenson, W. Tepp and B. R. DasGupta (1991) Crystallization and preliminary X-ray analysis of botulinum neurotoxin type A J Mol Biol 222: 877-80 ;
19.	R. C. Stevens, K. M. Reinisch and W. N. Lipscomb (1991) Molecular structure of Bacillus subtilis aspartate transcarbamoylase at 3.0 A resolution Proc Natl Acad Sci U S A 88: 6087-91 ;
18.	R. C. Stevens, J. S. Ricci, T. F. Koetzle and W. A. Hermann (1991) Transition metal methylene complexes. LXVII. Neutron diffraction study of a m-propylidene(2)-bis[carbonyl(h5-pentamethyl-cyclopentadienyl)-rhodium-(Rh-Rh)], [m-C(CH3)2]¬[{h5C5(CH3)5}Rh(CO)]2, at 20 K J Organomet Chem 412: 425-434 ;

Publications - 1990

17.	K. M. Doxsee and R. C. Stevens (1990) Complexation-mediated crystallization: Crystallization of sodium acetate trihydrate needles from cyclohexane solution J Incl Phenom Mol Recognit Chem 9: 327 ;
16.	J. E. Gouaux, R. C. Stevens and W. N. Lipscomb (1990) Crystal structures of aspartate carbamoyltransferase ligated with phosphonoacetamide, malonate, and CTP or ATP at 2.8-A resolution and neutral pH Biochemistry 29: 7702-15 ;
15.	R. K. McMullen, R. C. Stevens and J. S. Ricci (1990) The crystal structure of Sr(OH)2,8H2O at 20 K, 100 K, and 200 K by neutron diffraction Acta Crystallogr A 46S: C291 ;
14.	R. C. Stevens, R. Bau, R. E. Cramer, D. Afzal, J. W. Gilje and T. F. Koetzle (1990) Multiple-bond character in Cp3U=CHPMe3: First low-temperature neutron diffraction analysis of a uranium organometallic complex Organometallics 9: 694-697 ;
13.	R. C. Stevens, R. Bau, D. Milstein, O. Blum and T. F. Koetzle (1990) Concept of the H(d+)...H(d ) interaction. A low-temperature neutron diffraction study of cis-[IrH(OH)(PMe3)4]PF6 J Chem Soc Dalton Trans 1429-1432 ;
12.	R. C. Stevens, J. E. Gouaux and W. N. Lipscomb (1990) Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution Biochemistry 29: 7691-701 ;
11.	R. C. Stevens and W. N. Lipscomb (1990) Allosteric control of quaternary states in E. coli aspartate transcarbamylase Biochem Biophys Res Commun 171: 1312-8 ;

Publications - 1989

10.	J. E. Gouaux, R. C. Stevens, H. M. Ke and W. N. Lipscomb (1989) Crystal structure of the Glu-239----Gln mutant of aspartate carbamoyltransferase at 3.1-A resolution: an intermediate quaternary structure Proc Natl Acad Sci U S A 86: 8212-6 ;
9.	M. R. McLean, R. C. Stevens, R. Bau and T. F. Koetzle (1989) Location of the elusive hydride ligand in HRh[P(C6H5)3]4 via a neutron diffraction analysis Inorg Chim Acta 166: 173-175 ;
8.	R. C. Stevens, M. R. McLean, R. Bau and T. F. Koetzle (1989) Neutron diffraction structure analysis of a hexanuclear copper hydrido complex, H6Cu6[P(p-tolyl)3]6: An unexpected finding J Am Chem Soc 111: 3472-3473 ;
7.	R. C. Stevens, M. R. McLean, T. Wen, J. D. Carpenter, R. Bau and T. F. Koetzle (1989) An X-ray and neutron diffraction structure analysis of a triply-bridged binuclear iridium complex, [[(C5(CH3)5Ir)2(m-H)3]+[ClO4]-•2C6H6] Inorg Chim Acta 161: 223-231 ;

Publications - 1988

6.	R. Bau, R. C. Stevens, M. R. McLean and T. F. Koetzle (1988) Neutron diffraction analysis of HRh[P(C6H5)3]4 M. M. Elcombe and T. J. Hicks Materials Science Forum 27/28 Switzerland Trans Tech Publications LTD 77-80
5.	H. K. Choi, A. Terzis, R. C. Stevens, R. Bau, R. Haugwitz, V. L. Narayanan and M. Wolpert-DeFilippes (1988) Reaction products of a new anti-cancer agent, Pt(IV)(cyclohexyldiamine)Cl4, with guanosine and 9-methylguanine: first crystal structures of Pt(cyclohexyldiamine) complexes with a nucleobase and a nucleoside Biochem Biophys Res Commun 156: 1120-4 ;
4.	G. A. Olah, O. Farooq, S. M. F. Farina, M. R. Bruce, F. L. Clouet, P. R. Morton, G. K. S. Prakash, R. C. Stevens, R. Bau, K. Lammertsma, S. Suzer and L. Andrews (1988) Aluminum dichloride and dibromide. preparation, spectroscopic (including matrix isolation) study, reactions, and role (together with alkyl(aryl)aluminum monohalides) in the preparation of organoaluminum compounds J Am Chem Soc 110: 3231-3286 ;
3.	H. S. Yuan, R. C. Stevens, S. Fujita, M. I. Watkins, T. F. Koetzle and R. Bau (1988) Determination of the absolute configuration of (-)-(2R)-succinic-2-d acid by neutron diffraction study: unambiguous proof of the absolute stereochemistry of the NAD+/NADH interconversion Proc Natl Acad Sci U S A 85: 2889-93 ;

Publications - 1987

2.	G. K. S. Prakash, S. Keyaniyan, R. Aniszfeld, L. Heiliger, G. A. Olah, R. C. Stevens, H. Choi and R. Bau (1987) Triphenylsiyl perchlorate revisited: 29Si and 35Cl NMR spectroscopy and X-ray crystallography showing covalent nature in both solution and the solid state. Difficulties in observing long-lived silyl cations in the condensed state J Am Chem Soc 109: 5123-5126 ;
1.	R. C. Stevens, M. R. McLean, R. Bau and T. F. Koetzle (1987) Neutron diffraction analysis of [(C5Me5)Ir(m-H)3Ir(C5Me5)]+[ClO4]-C6H6 Acta Crystallogr A 43S: C-176 ;