Published in reference R.C. Stevens. "The cost and value of three-dimensional protein structure" Drug Discovery World, 4, 35-48 (2003).
| HIV protease | bcl-2 |
| renin | neuraminidase |
| factor Xa | glyceraldehyde-3-phosphate dehydrogenase |
| thrombin | interleukin-1b-converting enzyme (ICE, caspase-1) |
| factor VIIa/TF | thymidylate synthase |
| urokinase | protein-tyrosine phosphatase |
| urokinase-type plasminogen activator | acetylcholinesterase |
| rhinovirus 3C protease | prostaglandin receptor |
| cathepsin B, L, and S | matrix metalloproteinase (MMP) |
| 20S proteasome (chymotrypsin-activity) | trihydroxynaphthalene reductase (3HNR) |
| memapsin 2 (beta-secretase) | dihydrofolate reductase (MAC vs human) |
| Abl kinase | cyclooxygenase-2 |
| CDKs | neuronal nicotinic receptor agonists |
| EGFR kinase | 5 a-reductase |
| Lck kinase | monoamine oxidase-B |
| Src kinase | N-myristoyl transferase |
| aldose reductase | hypoxanthine-guanine-xanthine phosphoribosyltransferase |
| phospholipase-A2 | DNA gyrase |
| STAT | human carbonic anhydrase II |
| bcl-2 | peptide deformylase |
| DPP4 | HDAC |
last updated December 18, 2003 - send corrections and comments to Angela Walker (alwalker@scripps.edu)